User login
Prescribing Patterns of Onychomycosis Therapies in the United States
To the Editor:
Onychomycosis is the most common nail disorder, affecting approximately 5.5% of the world’s population.1 There are a limited number of topical and systemic therapies approved by the US Food and Drug Administration (FDA), but no consensus guidelines exist for the management of onychomycosis. Therefore, we hypothesized that prescribing patterns would vary among different groups.
We examined data from the Centers for Medicare & Medicaid Services’ Part D Prescriber Public Use Files for 2013 to 2016.2 Prescribing patterns were assessed for dermatologists, nurse practitioners, physician assistants, and podiatrists prescribing systemic (ie, terbinafine, itraconazole) or topical (ie, efinaconazole, tavaborole, ciclopirox) therapies. A cut-off of systemic therapy lasting 84 days or more (reflecting FDA-approved treatment regimens for toenail onychomycosis) was used to exclude prescriptions for other fungal conditions that require shorter treatment courses. Statistical analysis with χ2 tests identified differences among specialties’ prescribing patterns.
Overall, onychomycosis medications accounted for $85.4 million in expenditures from 2013 to 2016, with spending increasing at a rate of 21.2% annually (Table 1). The greatest single-year increase was observed from 2014 to 2015, with a 40.6% surge in overall expenditures for onychomycosis medications—increasing from $17.8 million to $25.0 million in spending. Dermatologists’ prescriptions accounted for 14.8% of all claims for onychomycosis medications and 18.3% of total expenditures during the study period, totaling $15.7 million in costs. Dermatologists’ claims increased at a rate of 7.4% annually, while expenditures increased at 15.4% annually. A greater proportion of dermatologists (96.4%) prescribed topicals for onychomycosis relative to nurse practitioners (90.2%) and podiatrists (91.3%)(P<.01)(Table 2). No significant difference was observed in the prescribing patterns of dermatologists and physician assistants (P=.99).
Per-claim spending for treating onychomycosis increased 7.4% annually for dermatologists, second only to podiatrists at 17.2% annually. Each analyzed group reported at least a 7% annual increase in the amount of topicals prescribed for onychomycosis. Following their FDA approvals in 2014, tavaborole and efinaconazole accounted for 0.9% and 2.3% of onychomycosis claims in 2016, respectively, and 15.0% and 25.1% of total Medicare expenditures on onychomycosis treatments that same year, respectively. Itraconazole also disproportionately contributed to expenditures, accounting for 1.3% of onychomycosis claims in 2016 while accounting for 9.5% of total expenditures.
The introduction of efinaconazole and tavaborole in 2014 resulted in large increases in Medicare spending for onychomycosis. Limited manufacturer competition due to patents may contribute to increased spending on these topicals in the future.3 A prior analysis demonstrated that podiatrists prescribe topicals more often than other clinicians,4 but after adjusting for the number of dermatologists managing onychomycosis, we found that a greater proportion of dermatologists (96.4%) are prescribing topicals for onychomycosis than other clinicians. This includes these newly approved, high-cost topicals, thus disproportionately contributing to the cost burden of onychomycosis treatment.
Ciclopirox is the most commonly prescribed therapy for onychomycosis across all groups, prescribed by more than 88% of prescribers in all studied specialties. Although ciclopirox is one of the least expensive treatment options available for onychomycosis, it has the lowest relative cure rate.5 Onychomycosis management requires understanding of drug efficacy and disease severity.6 Inappropriate treatment selection may result in prolonged treatment courses and increased costs. Consensus guidelines for onychomycosis therapies across specialties may yield more cost-effective treatment for this common nail condition.
Acknowledgment
The authors thank Paul J. Christos, DrPH, MS (New York, New York), for his advisement regarding statistical analysis for this manuscript.
- Lipner SR, Scher RK. Onychomycosis: clinical overview and diagnosis. J Am Acad Dermatol. 2019;80:835-851.
- Medicare provider utilization and payment data: part D prescriber. Centers for Medicare & Medicaid Services website. https://www.cms.gov/Research-Statistics-Data-and-Systems/Statistics-Trends-and-Reports/Medicare-Provider-Charge-Data/Part-D-Prescriber. Updated November 27, 2019. Accessed November 22, 2020.
- Yang EJ, Lipner SR. Pharmacy costs of medications for the treatment of onychomycosis in the United States. J Am Acad Dermatol. 2019;81:276-278.
- Singh P, Silverberg JI. Trends in utilization and expenditure for onychomycosis treatments in the United States in 2013-2016. Am J Clin Dermatol. 2019;20:311-313.
- Lipner SR, Scher RK. Onychomycosis: treatment and prevention of recurrence. J Am Acad Dermatol. 2019;80:853-867.
- Lipner SR. Pharmacotherapy for onychomycosis: new and emerging treatments. Expert Opin Pharmacother. 2019;20:725-735.
To the Editor:
Onychomycosis is the most common nail disorder, affecting approximately 5.5% of the world’s population.1 There are a limited number of topical and systemic therapies approved by the US Food and Drug Administration (FDA), but no consensus guidelines exist for the management of onychomycosis. Therefore, we hypothesized that prescribing patterns would vary among different groups.
We examined data from the Centers for Medicare & Medicaid Services’ Part D Prescriber Public Use Files for 2013 to 2016.2 Prescribing patterns were assessed for dermatologists, nurse practitioners, physician assistants, and podiatrists prescribing systemic (ie, terbinafine, itraconazole) or topical (ie, efinaconazole, tavaborole, ciclopirox) therapies. A cut-off of systemic therapy lasting 84 days or more (reflecting FDA-approved treatment regimens for toenail onychomycosis) was used to exclude prescriptions for other fungal conditions that require shorter treatment courses. Statistical analysis with χ2 tests identified differences among specialties’ prescribing patterns.
Overall, onychomycosis medications accounted for $85.4 million in expenditures from 2013 to 2016, with spending increasing at a rate of 21.2% annually (Table 1). The greatest single-year increase was observed from 2014 to 2015, with a 40.6% surge in overall expenditures for onychomycosis medications—increasing from $17.8 million to $25.0 million in spending. Dermatologists’ prescriptions accounted for 14.8% of all claims for onychomycosis medications and 18.3% of total expenditures during the study period, totaling $15.7 million in costs. Dermatologists’ claims increased at a rate of 7.4% annually, while expenditures increased at 15.4% annually. A greater proportion of dermatologists (96.4%) prescribed topicals for onychomycosis relative to nurse practitioners (90.2%) and podiatrists (91.3%)(P<.01)(Table 2). No significant difference was observed in the prescribing patterns of dermatologists and physician assistants (P=.99).
Per-claim spending for treating onychomycosis increased 7.4% annually for dermatologists, second only to podiatrists at 17.2% annually. Each analyzed group reported at least a 7% annual increase in the amount of topicals prescribed for onychomycosis. Following their FDA approvals in 2014, tavaborole and efinaconazole accounted for 0.9% and 2.3% of onychomycosis claims in 2016, respectively, and 15.0% and 25.1% of total Medicare expenditures on onychomycosis treatments that same year, respectively. Itraconazole also disproportionately contributed to expenditures, accounting for 1.3% of onychomycosis claims in 2016 while accounting for 9.5% of total expenditures.
The introduction of efinaconazole and tavaborole in 2014 resulted in large increases in Medicare spending for onychomycosis. Limited manufacturer competition due to patents may contribute to increased spending on these topicals in the future.3 A prior analysis demonstrated that podiatrists prescribe topicals more often than other clinicians,4 but after adjusting for the number of dermatologists managing onychomycosis, we found that a greater proportion of dermatologists (96.4%) are prescribing topicals for onychomycosis than other clinicians. This includes these newly approved, high-cost topicals, thus disproportionately contributing to the cost burden of onychomycosis treatment.
Ciclopirox is the most commonly prescribed therapy for onychomycosis across all groups, prescribed by more than 88% of prescribers in all studied specialties. Although ciclopirox is one of the least expensive treatment options available for onychomycosis, it has the lowest relative cure rate.5 Onychomycosis management requires understanding of drug efficacy and disease severity.6 Inappropriate treatment selection may result in prolonged treatment courses and increased costs. Consensus guidelines for onychomycosis therapies across specialties may yield more cost-effective treatment for this common nail condition.
Acknowledgment
The authors thank Paul J. Christos, DrPH, MS (New York, New York), for his advisement regarding statistical analysis for this manuscript.
To the Editor:
Onychomycosis is the most common nail disorder, affecting approximately 5.5% of the world’s population.1 There are a limited number of topical and systemic therapies approved by the US Food and Drug Administration (FDA), but no consensus guidelines exist for the management of onychomycosis. Therefore, we hypothesized that prescribing patterns would vary among different groups.
We examined data from the Centers for Medicare & Medicaid Services’ Part D Prescriber Public Use Files for 2013 to 2016.2 Prescribing patterns were assessed for dermatologists, nurse practitioners, physician assistants, and podiatrists prescribing systemic (ie, terbinafine, itraconazole) or topical (ie, efinaconazole, tavaborole, ciclopirox) therapies. A cut-off of systemic therapy lasting 84 days or more (reflecting FDA-approved treatment regimens for toenail onychomycosis) was used to exclude prescriptions for other fungal conditions that require shorter treatment courses. Statistical analysis with χ2 tests identified differences among specialties’ prescribing patterns.
Overall, onychomycosis medications accounted for $85.4 million in expenditures from 2013 to 2016, with spending increasing at a rate of 21.2% annually (Table 1). The greatest single-year increase was observed from 2014 to 2015, with a 40.6% surge in overall expenditures for onychomycosis medications—increasing from $17.8 million to $25.0 million in spending. Dermatologists’ prescriptions accounted for 14.8% of all claims for onychomycosis medications and 18.3% of total expenditures during the study period, totaling $15.7 million in costs. Dermatologists’ claims increased at a rate of 7.4% annually, while expenditures increased at 15.4% annually. A greater proportion of dermatologists (96.4%) prescribed topicals for onychomycosis relative to nurse practitioners (90.2%) and podiatrists (91.3%)(P<.01)(Table 2). No significant difference was observed in the prescribing patterns of dermatologists and physician assistants (P=.99).
Per-claim spending for treating onychomycosis increased 7.4% annually for dermatologists, second only to podiatrists at 17.2% annually. Each analyzed group reported at least a 7% annual increase in the amount of topicals prescribed for onychomycosis. Following their FDA approvals in 2014, tavaborole and efinaconazole accounted for 0.9% and 2.3% of onychomycosis claims in 2016, respectively, and 15.0% and 25.1% of total Medicare expenditures on onychomycosis treatments that same year, respectively. Itraconazole also disproportionately contributed to expenditures, accounting for 1.3% of onychomycosis claims in 2016 while accounting for 9.5% of total expenditures.
The introduction of efinaconazole and tavaborole in 2014 resulted in large increases in Medicare spending for onychomycosis. Limited manufacturer competition due to patents may contribute to increased spending on these topicals in the future.3 A prior analysis demonstrated that podiatrists prescribe topicals more often than other clinicians,4 but after adjusting for the number of dermatologists managing onychomycosis, we found that a greater proportion of dermatologists (96.4%) are prescribing topicals for onychomycosis than other clinicians. This includes these newly approved, high-cost topicals, thus disproportionately contributing to the cost burden of onychomycosis treatment.
Ciclopirox is the most commonly prescribed therapy for onychomycosis across all groups, prescribed by more than 88% of prescribers in all studied specialties. Although ciclopirox is one of the least expensive treatment options available for onychomycosis, it has the lowest relative cure rate.5 Onychomycosis management requires understanding of drug efficacy and disease severity.6 Inappropriate treatment selection may result in prolonged treatment courses and increased costs. Consensus guidelines for onychomycosis therapies across specialties may yield more cost-effective treatment for this common nail condition.
Acknowledgment
The authors thank Paul J. Christos, DrPH, MS (New York, New York), for his advisement regarding statistical analysis for this manuscript.
- Lipner SR, Scher RK. Onychomycosis: clinical overview and diagnosis. J Am Acad Dermatol. 2019;80:835-851.
- Medicare provider utilization and payment data: part D prescriber. Centers for Medicare & Medicaid Services website. https://www.cms.gov/Research-Statistics-Data-and-Systems/Statistics-Trends-and-Reports/Medicare-Provider-Charge-Data/Part-D-Prescriber. Updated November 27, 2019. Accessed November 22, 2020.
- Yang EJ, Lipner SR. Pharmacy costs of medications for the treatment of onychomycosis in the United States. J Am Acad Dermatol. 2019;81:276-278.
- Singh P, Silverberg JI. Trends in utilization and expenditure for onychomycosis treatments in the United States in 2013-2016. Am J Clin Dermatol. 2019;20:311-313.
- Lipner SR, Scher RK. Onychomycosis: treatment and prevention of recurrence. J Am Acad Dermatol. 2019;80:853-867.
- Lipner SR. Pharmacotherapy for onychomycosis: new and emerging treatments. Expert Opin Pharmacother. 2019;20:725-735.
- Lipner SR, Scher RK. Onychomycosis: clinical overview and diagnosis. J Am Acad Dermatol. 2019;80:835-851.
- Medicare provider utilization and payment data: part D prescriber. Centers for Medicare & Medicaid Services website. https://www.cms.gov/Research-Statistics-Data-and-Systems/Statistics-Trends-and-Reports/Medicare-Provider-Charge-Data/Part-D-Prescriber. Updated November 27, 2019. Accessed November 22, 2020.
- Yang EJ, Lipner SR. Pharmacy costs of medications for the treatment of onychomycosis in the United States. J Am Acad Dermatol. 2019;81:276-278.
- Singh P, Silverberg JI. Trends in utilization and expenditure for onychomycosis treatments in the United States in 2013-2016. Am J Clin Dermatol. 2019;20:311-313.
- Lipner SR, Scher RK. Onychomycosis: treatment and prevention of recurrence. J Am Acad Dermatol. 2019;80:853-867.
- Lipner SR. Pharmacotherapy for onychomycosis: new and emerging treatments. Expert Opin Pharmacother. 2019;20:725-735.
Practice Points
- Dermatologists should consider efficacy and cost of onychomycosis therapies, as inappropriate treatment selection results in longer treatment courses and increased costs.
- Creation of consensus guidelines for the management of onychomycosis may decrease the costs of treating this difficult-to-manage disease.
Use of 3D Technology to Support Dermatologists Returning to Practice Amid COVID-19
Coronavirus disease 2019 (COVID-19) has spread across all 7 continents, including 185 countries, and infected more than 21.9 million individuals worldwide as of August 18, 2020, according to the Johns Hopkins Coronavirus Resource Center. It has strained our health care system and affected all specialties, including dermatology. Dermatologists have taken important safety measures by canceling/deferring elective and nonemergency procedures and diagnosing/treating patients via telemedicine. Many residents and attending dermatologists have volunteered to care for COVID-19 inpatients and donated
N95 masks are necessary during the COVID-19 pandemic because they effectively filter at least 95% of 0.3-μm airborne particles and provide adequate face seals.1 3-Dimensional imaging integrated with 3D printers can be used to scan precise facial parameters (eg, jawline, nose) and account for facial hair density and length to produce comfortable tailored N95 masks and face seals.1,2 3-Dimensional printing utilizes robotics and
Face shields offer an additional layer of safety for the face and mucosae and also may provide longevity for N95 masks. Using synthetic polymers such as polycarbonate and polyethylene, 3D printers can be used to construct face shields via fused deposition modeling.1 These face shields may be worn over N95 masks and then can be sanitized and reused.
Mohs surgeons and staff may be at particularly high risk for COVID-19 infection due to their close proximity to the face during surgery, use of cautery, and prolonged time spent with patients while taking layers and suturing.

As dermatologists reopen and ramp up practice volume, there will be increased PPE requirements. Using 3D technology and imaging to produce N95 masks, face shields, and face coverings, we can offer effective diagnosis and treatment while optimizing safety for dermatologists, staff, and patients.
- Ishack S, Lipner SR. Applications of 3D printing technology to address COVID-19-related supply shortages [published online April 21, 2020]. Am J Med. 2020;133:771-773.
- Cai M, Li H, Shen S, et al. Customized design and 3D printing of face seal for an N95 filtering facepiece respirator. J Occup Environ Hyg. 2018;3:226-234.
- Ishack S, Lipner SR. A review of 3-dimensional skin bioprinting techniques: applications, approaches, and trends [published online March 17, 2020]. Dermatol Surg. doi:10.1097/DSS.0000000000002378.
- Banerjee SS, Burbine S, Shivaprakash NK, et al. 3D-printable PP/SEBS thermoplastic elastomeric blends: preparation and properties [published online February 17, 2019]. Polymers (Basel). doi:10.3390/polym11020347.
- Chuah SY, Attia ABE, Long V. Structural and functional 3D mapping of skin tumours with non-invasive multispectral optoacoustic tomography [published online November 2, 2016]. Skin Res Technol. 2017;23:221-226.
Coronavirus disease 2019 (COVID-19) has spread across all 7 continents, including 185 countries, and infected more than 21.9 million individuals worldwide as of August 18, 2020, according to the Johns Hopkins Coronavirus Resource Center. It has strained our health care system and affected all specialties, including dermatology. Dermatologists have taken important safety measures by canceling/deferring elective and nonemergency procedures and diagnosing/treating patients via telemedicine. Many residents and attending dermatologists have volunteered to care for COVID-19 inpatients and donated
N95 masks are necessary during the COVID-19 pandemic because they effectively filter at least 95% of 0.3-μm airborne particles and provide adequate face seals.1 3-Dimensional imaging integrated with 3D printers can be used to scan precise facial parameters (eg, jawline, nose) and account for facial hair density and length to produce comfortable tailored N95 masks and face seals.1,2 3-Dimensional printing utilizes robotics and
Face shields offer an additional layer of safety for the face and mucosae and also may provide longevity for N95 masks. Using synthetic polymers such as polycarbonate and polyethylene, 3D printers can be used to construct face shields via fused deposition modeling.1 These face shields may be worn over N95 masks and then can be sanitized and reused.
Mohs surgeons and staff may be at particularly high risk for COVID-19 infection due to their close proximity to the face during surgery, use of cautery, and prolonged time spent with patients while taking layers and suturing.

As dermatologists reopen and ramp up practice volume, there will be increased PPE requirements. Using 3D technology and imaging to produce N95 masks, face shields, and face coverings, we can offer effective diagnosis and treatment while optimizing safety for dermatologists, staff, and patients.
Coronavirus disease 2019 (COVID-19) has spread across all 7 continents, including 185 countries, and infected more than 21.9 million individuals worldwide as of August 18, 2020, according to the Johns Hopkins Coronavirus Resource Center. It has strained our health care system and affected all specialties, including dermatology. Dermatologists have taken important safety measures by canceling/deferring elective and nonemergency procedures and diagnosing/treating patients via telemedicine. Many residents and attending dermatologists have volunteered to care for COVID-19 inpatients and donated
N95 masks are necessary during the COVID-19 pandemic because they effectively filter at least 95% of 0.3-μm airborne particles and provide adequate face seals.1 3-Dimensional imaging integrated with 3D printers can be used to scan precise facial parameters (eg, jawline, nose) and account for facial hair density and length to produce comfortable tailored N95 masks and face seals.1,2 3-Dimensional printing utilizes robotics and
Face shields offer an additional layer of safety for the face and mucosae and also may provide longevity for N95 masks. Using synthetic polymers such as polycarbonate and polyethylene, 3D printers can be used to construct face shields via fused deposition modeling.1 These face shields may be worn over N95 masks and then can be sanitized and reused.
Mohs surgeons and staff may be at particularly high risk for COVID-19 infection due to their close proximity to the face during surgery, use of cautery, and prolonged time spent with patients while taking layers and suturing.

As dermatologists reopen and ramp up practice volume, there will be increased PPE requirements. Using 3D technology and imaging to produce N95 masks, face shields, and face coverings, we can offer effective diagnosis and treatment while optimizing safety for dermatologists, staff, and patients.
- Ishack S, Lipner SR. Applications of 3D printing technology to address COVID-19-related supply shortages [published online April 21, 2020]. Am J Med. 2020;133:771-773.
- Cai M, Li H, Shen S, et al. Customized design and 3D printing of face seal for an N95 filtering facepiece respirator. J Occup Environ Hyg. 2018;3:226-234.
- Ishack S, Lipner SR. A review of 3-dimensional skin bioprinting techniques: applications, approaches, and trends [published online March 17, 2020]. Dermatol Surg. doi:10.1097/DSS.0000000000002378.
- Banerjee SS, Burbine S, Shivaprakash NK, et al. 3D-printable PP/SEBS thermoplastic elastomeric blends: preparation and properties [published online February 17, 2019]. Polymers (Basel). doi:10.3390/polym11020347.
- Chuah SY, Attia ABE, Long V. Structural and functional 3D mapping of skin tumours with non-invasive multispectral optoacoustic tomography [published online November 2, 2016]. Skin Res Technol. 2017;23:221-226.
- Ishack S, Lipner SR. Applications of 3D printing technology to address COVID-19-related supply shortages [published online April 21, 2020]. Am J Med. 2020;133:771-773.
- Cai M, Li H, Shen S, et al. Customized design and 3D printing of face seal for an N95 filtering facepiece respirator. J Occup Environ Hyg. 2018;3:226-234.
- Ishack S, Lipner SR. A review of 3-dimensional skin bioprinting techniques: applications, approaches, and trends [published online March 17, 2020]. Dermatol Surg. doi:10.1097/DSS.0000000000002378.
- Banerjee SS, Burbine S, Shivaprakash NK, et al. 3D-printable PP/SEBS thermoplastic elastomeric blends: preparation and properties [published online February 17, 2019]. Polymers (Basel). doi:10.3390/polym11020347.
- Chuah SY, Attia ABE, Long V. Structural and functional 3D mapping of skin tumours with non-invasive multispectral optoacoustic tomography [published online November 2, 2016]. Skin Res Technol. 2017;23:221-226.
Practice Points
- Coronavirus disease 19 has overwhelmed our health care system and affected all specialties, including dermatology.
- There are concerns about shortages of personal protective equipment to safely care for patients.
- 3-Dimensional imaging and printing technologies can be harnessed to create face coverings and face shields for the dermatology outpatient setting.
Approximation of Alcohol-Based Hand Sanitizer Volume Using a Toothpaste Cap
Practice Gap
The Centers for Disease Control and Prevention recommends handwashing with soap and water or using alcohol-based hand sanitizers to prevent transmission of coronavirus disease 2019. Five steps are delineated for effective handwashing: wetting, lathering, scrubbing, rinsing, and drying. Although alcohol-based sanitizers may be perceived as more damaging to the skin, they are less likely to cause dermatitis than handwashing with soap and water.1 Instructions are precise for handwashing, while there are no recommendations for effective use of alcohol-based hand sanitizers. A common inquiry regarding alcohol-based hand sanitizers is the volume needed for efficacy without causing skin irritation.
The Technique
Approximately 1 mL of alcohol-based hand sanitizer is recommended by some manufacturers. However, abundant evidence refutes this recommendation, including a study that tested the microbial efficacy of alcohol-based sanitizers by volume. A volume of 2 mL was necessary to achieve the 2.0 log reduction of contaminants as required by the US Food and Drug Administration for antimicrobial efficacy.2 The precise measurement of hand sanitizer using a calibrated syringe before each use is impractical. Thus, we recommend using a screw-top toothpaste cap to assist in approximating the necessary volume (Figure). The cap holds approximately 1 mL of liquid as measured using a syringe; therefore, 2 caps filled with sanitizer should be used.

Practice Implications
The general public may be underutilizing hand sanitizer due to fear of excessive skin irritation or supply shortages, which will reduce efficacy. Patients and physicians can use this simple visual approximation to ensure adequate use of hand sanitizer volume.
- Stutz N, Becker D, Jappe U, et al. Nurses’ perceptions of the benefits and adverse effects of hand disinfection: alcohol-based hand rubs vs. hygienic handwashing: a multicentre questionnaire study with additional patch testing by the German Contact Dermatitis Research Group. Br J Dermatol. 2009;160:565-572.
- Kampf G, Ruselack S, Eggerstedt S, et al. Less and less-influence of volume on hand coverage and bactericidal efficacy in hand disinfection. BMC Infect Dis. 2013;13:472.
Practice Gap
The Centers for Disease Control and Prevention recommends handwashing with soap and water or using alcohol-based hand sanitizers to prevent transmission of coronavirus disease 2019. Five steps are delineated for effective handwashing: wetting, lathering, scrubbing, rinsing, and drying. Although alcohol-based sanitizers may be perceived as more damaging to the skin, they are less likely to cause dermatitis than handwashing with soap and water.1 Instructions are precise for handwashing, while there are no recommendations for effective use of alcohol-based hand sanitizers. A common inquiry regarding alcohol-based hand sanitizers is the volume needed for efficacy without causing skin irritation.
The Technique
Approximately 1 mL of alcohol-based hand sanitizer is recommended by some manufacturers. However, abundant evidence refutes this recommendation, including a study that tested the microbial efficacy of alcohol-based sanitizers by volume. A volume of 2 mL was necessary to achieve the 2.0 log reduction of contaminants as required by the US Food and Drug Administration for antimicrobial efficacy.2 The precise measurement of hand sanitizer using a calibrated syringe before each use is impractical. Thus, we recommend using a screw-top toothpaste cap to assist in approximating the necessary volume (Figure). The cap holds approximately 1 mL of liquid as measured using a syringe; therefore, 2 caps filled with sanitizer should be used.

Practice Implications
The general public may be underutilizing hand sanitizer due to fear of excessive skin irritation or supply shortages, which will reduce efficacy. Patients and physicians can use this simple visual approximation to ensure adequate use of hand sanitizer volume.
Practice Gap
The Centers for Disease Control and Prevention recommends handwashing with soap and water or using alcohol-based hand sanitizers to prevent transmission of coronavirus disease 2019. Five steps are delineated for effective handwashing: wetting, lathering, scrubbing, rinsing, and drying. Although alcohol-based sanitizers may be perceived as more damaging to the skin, they are less likely to cause dermatitis than handwashing with soap and water.1 Instructions are precise for handwashing, while there are no recommendations for effective use of alcohol-based hand sanitizers. A common inquiry regarding alcohol-based hand sanitizers is the volume needed for efficacy without causing skin irritation.
The Technique
Approximately 1 mL of alcohol-based hand sanitizer is recommended by some manufacturers. However, abundant evidence refutes this recommendation, including a study that tested the microbial efficacy of alcohol-based sanitizers by volume. A volume of 2 mL was necessary to achieve the 2.0 log reduction of contaminants as required by the US Food and Drug Administration for antimicrobial efficacy.2 The precise measurement of hand sanitizer using a calibrated syringe before each use is impractical. Thus, we recommend using a screw-top toothpaste cap to assist in approximating the necessary volume (Figure). The cap holds approximately 1 mL of liquid as measured using a syringe; therefore, 2 caps filled with sanitizer should be used.

Practice Implications
The general public may be underutilizing hand sanitizer due to fear of excessive skin irritation or supply shortages, which will reduce efficacy. Patients and physicians can use this simple visual approximation to ensure adequate use of hand sanitizer volume.
- Stutz N, Becker D, Jappe U, et al. Nurses’ perceptions of the benefits and adverse effects of hand disinfection: alcohol-based hand rubs vs. hygienic handwashing: a multicentre questionnaire study with additional patch testing by the German Contact Dermatitis Research Group. Br J Dermatol. 2009;160:565-572.
- Kampf G, Ruselack S, Eggerstedt S, et al. Less and less-influence of volume on hand coverage and bactericidal efficacy in hand disinfection. BMC Infect Dis. 2013;13:472.
- Stutz N, Becker D, Jappe U, et al. Nurses’ perceptions of the benefits and adverse effects of hand disinfection: alcohol-based hand rubs vs. hygienic handwashing: a multicentre questionnaire study with additional patch testing by the German Contact Dermatitis Research Group. Br J Dermatol. 2009;160:565-572.
- Kampf G, Ruselack S, Eggerstedt S, et al. Less and less-influence of volume on hand coverage and bactericidal efficacy in hand disinfection. BMC Infect Dis. 2013;13:472.
Assessment of Nail Content in the American Academy of Dermatology Patient Education Website
To the Editor:
Patients with skin, hair, or nail concerns often utilize online resources to self-diagnose or learn more about physician-diagnosed conditions. The American Academy of Dermatology (AAD) website offers the public access to informational pages categorized by disease or treatment (https://www.aad.org/public). We sought to evaluate the nail content by searching the Patients and Public section of the AAD website to qualitatively and quantitatively describe mentions of nail conditions. Psoriasis, psoriatic arthritis, atopic dermatitis, and ringworm content also were analyzed and compared to nail content. The analysis was performed on September 7, 2019.
Of the 73 topics listed in the Diseases and Treatments section of the site, 17 (23%) specifically mentioned nail symptoms or pathology (Table). Three additional topics—atopic dermatitis, cellulitis, and neurodermatitis—recommended keeping nails short to prevent injury from scratching. There was 1 mention of obtaining fungal cultures, 2 of nail scraping microscopy, 2 of nail clippings, and 2 of nail-related cancers. There were no mentions of nail biopsies. The total number of unique clinical images across all sections was 300, with 12 of nails. The video library contained 84 videos, of which 6 focused on nail health.
Our study demonstrated that nail content is underrepresented in the public education section of the AAD website. If patients are unable to find nail disease material on the AAD website, they may seek alternative sources that are unreliable. Prior studies have shown that patient Internet resources for subungual melanoma and onychomycosis often are inadequate in quality and readability.1,2
Representative photographs and key information on common nail diseases could be added to improve patient education. The atopic dermatitis section should include text on related nail changes with accompanying images. We also recommend including paronychia information and images as either a separate topic or in the cellulitis section. The contact dermatitis section mentions nail cosmetics as causative factors, but an image of roller-coaster onycholysis may be more helpful.3 Although the alopecia areata section mentions nail changes, this information should be added to the general hair loss section of the site, as many patients may initially seek out the latter category. Herpes simplex may affect nails, and an image showing these changes would be instructive. In addition, pyogenic granulomas and paronychia occur with isotretinoin use.4
Many of the included images were not representative of common clinical findings. The nail lichen planus image showed pitting instead of more typical findings of nail plate atrophy and pterygium. The nail melanoma image showed thickened yellow toenails and the fifth toenail with a thin gray-brown band instead of an isolated wide black band. The nail fungus section included images of superficial onychomycosis and severe onychodystrophy instead of showing more common changes such as distal onycholysis with subungual hyperkeratosis, which is typical of the most common subtype, distal lateral subungual onychomycosis.5 Onychomycosis was referenced again in the ringworm section with 1 image repeated from the nail fungus section and another image that appeared to be a subungual hematoma.
The AAD website offers important patient education resources; however, nail content is underrepresented on this platform. Dermatologists are experts on nail disease, and increased efforts are needed to educate the public about frequently encountered nail signs and symptoms that could signify a serious underlying condition.
After our original search and analysis, new nail topics, images, and videos have been added; therefore, there has been a positive trend toward new nail content being added to site, which will greatly benefit patients.
- Kang R, Lipner S. Assessment of internet sources on subungual melanoma [published online August 30, 2018]. Melanoma Res. doi:10.1097/CMR.0000000000000508.
- Kang R, Lipner S. Evaluation of onychomycosis information on the internet. J Drugs Dermatol. 2019;18:484-487.
- Rieder EA, Tosti A. Cosmetically induced disorders of the nail with update on contemporary nail manicures. J Clin Aesthet Dermatol. 2016;9:39-44.
- Arias-Santiago S, Husein-ElAhmed H, Aneiros-Cachaza J, et al. Uncommon side effects of isotretinoin therapy: paronychia and pyogenic granuloma. J Am Acad Dermatol. 2011;64:AB37.
- Lipner SR, Scher RK. Onychomycosis: clinical overview and diagnosis. J Am Acad Dermatol. 2019;80:835-851.
To the Editor:
Patients with skin, hair, or nail concerns often utilize online resources to self-diagnose or learn more about physician-diagnosed conditions. The American Academy of Dermatology (AAD) website offers the public access to informational pages categorized by disease or treatment (https://www.aad.org/public). We sought to evaluate the nail content by searching the Patients and Public section of the AAD website to qualitatively and quantitatively describe mentions of nail conditions. Psoriasis, psoriatic arthritis, atopic dermatitis, and ringworm content also were analyzed and compared to nail content. The analysis was performed on September 7, 2019.
Of the 73 topics listed in the Diseases and Treatments section of the site, 17 (23%) specifically mentioned nail symptoms or pathology (Table). Three additional topics—atopic dermatitis, cellulitis, and neurodermatitis—recommended keeping nails short to prevent injury from scratching. There was 1 mention of obtaining fungal cultures, 2 of nail scraping microscopy, 2 of nail clippings, and 2 of nail-related cancers. There were no mentions of nail biopsies. The total number of unique clinical images across all sections was 300, with 12 of nails. The video library contained 84 videos, of which 6 focused on nail health.
Our study demonstrated that nail content is underrepresented in the public education section of the AAD website. If patients are unable to find nail disease material on the AAD website, they may seek alternative sources that are unreliable. Prior studies have shown that patient Internet resources for subungual melanoma and onychomycosis often are inadequate in quality and readability.1,2
Representative photographs and key information on common nail diseases could be added to improve patient education. The atopic dermatitis section should include text on related nail changes with accompanying images. We also recommend including paronychia information and images as either a separate topic or in the cellulitis section. The contact dermatitis section mentions nail cosmetics as causative factors, but an image of roller-coaster onycholysis may be more helpful.3 Although the alopecia areata section mentions nail changes, this information should be added to the general hair loss section of the site, as many patients may initially seek out the latter category. Herpes simplex may affect nails, and an image showing these changes would be instructive. In addition, pyogenic granulomas and paronychia occur with isotretinoin use.4
Many of the included images were not representative of common clinical findings. The nail lichen planus image showed pitting instead of more typical findings of nail plate atrophy and pterygium. The nail melanoma image showed thickened yellow toenails and the fifth toenail with a thin gray-brown band instead of an isolated wide black band. The nail fungus section included images of superficial onychomycosis and severe onychodystrophy instead of showing more common changes such as distal onycholysis with subungual hyperkeratosis, which is typical of the most common subtype, distal lateral subungual onychomycosis.5 Onychomycosis was referenced again in the ringworm section with 1 image repeated from the nail fungus section and another image that appeared to be a subungual hematoma.
The AAD website offers important patient education resources; however, nail content is underrepresented on this platform. Dermatologists are experts on nail disease, and increased efforts are needed to educate the public about frequently encountered nail signs and symptoms that could signify a serious underlying condition.
After our original search and analysis, new nail topics, images, and videos have been added; therefore, there has been a positive trend toward new nail content being added to site, which will greatly benefit patients.
To the Editor:
Patients with skin, hair, or nail concerns often utilize online resources to self-diagnose or learn more about physician-diagnosed conditions. The American Academy of Dermatology (AAD) website offers the public access to informational pages categorized by disease or treatment (https://www.aad.org/public). We sought to evaluate the nail content by searching the Patients and Public section of the AAD website to qualitatively and quantitatively describe mentions of nail conditions. Psoriasis, psoriatic arthritis, atopic dermatitis, and ringworm content also were analyzed and compared to nail content. The analysis was performed on September 7, 2019.
Of the 73 topics listed in the Diseases and Treatments section of the site, 17 (23%) specifically mentioned nail symptoms or pathology (Table). Three additional topics—atopic dermatitis, cellulitis, and neurodermatitis—recommended keeping nails short to prevent injury from scratching. There was 1 mention of obtaining fungal cultures, 2 of nail scraping microscopy, 2 of nail clippings, and 2 of nail-related cancers. There were no mentions of nail biopsies. The total number of unique clinical images across all sections was 300, with 12 of nails. The video library contained 84 videos, of which 6 focused on nail health.
Our study demonstrated that nail content is underrepresented in the public education section of the AAD website. If patients are unable to find nail disease material on the AAD website, they may seek alternative sources that are unreliable. Prior studies have shown that patient Internet resources for subungual melanoma and onychomycosis often are inadequate in quality and readability.1,2
Representative photographs and key information on common nail diseases could be added to improve patient education. The atopic dermatitis section should include text on related nail changes with accompanying images. We also recommend including paronychia information and images as either a separate topic or in the cellulitis section. The contact dermatitis section mentions nail cosmetics as causative factors, but an image of roller-coaster onycholysis may be more helpful.3 Although the alopecia areata section mentions nail changes, this information should be added to the general hair loss section of the site, as many patients may initially seek out the latter category. Herpes simplex may affect nails, and an image showing these changes would be instructive. In addition, pyogenic granulomas and paronychia occur with isotretinoin use.4
Many of the included images were not representative of common clinical findings. The nail lichen planus image showed pitting instead of more typical findings of nail plate atrophy and pterygium. The nail melanoma image showed thickened yellow toenails and the fifth toenail with a thin gray-brown band instead of an isolated wide black band. The nail fungus section included images of superficial onychomycosis and severe onychodystrophy instead of showing more common changes such as distal onycholysis with subungual hyperkeratosis, which is typical of the most common subtype, distal lateral subungual onychomycosis.5 Onychomycosis was referenced again in the ringworm section with 1 image repeated from the nail fungus section and another image that appeared to be a subungual hematoma.
The AAD website offers important patient education resources; however, nail content is underrepresented on this platform. Dermatologists are experts on nail disease, and increased efforts are needed to educate the public about frequently encountered nail signs and symptoms that could signify a serious underlying condition.
After our original search and analysis, new nail topics, images, and videos have been added; therefore, there has been a positive trend toward new nail content being added to site, which will greatly benefit patients.
- Kang R, Lipner S. Assessment of internet sources on subungual melanoma [published online August 30, 2018]. Melanoma Res. doi:10.1097/CMR.0000000000000508.
- Kang R, Lipner S. Evaluation of onychomycosis information on the internet. J Drugs Dermatol. 2019;18:484-487.
- Rieder EA, Tosti A. Cosmetically induced disorders of the nail with update on contemporary nail manicures. J Clin Aesthet Dermatol. 2016;9:39-44.
- Arias-Santiago S, Husein-ElAhmed H, Aneiros-Cachaza J, et al. Uncommon side effects of isotretinoin therapy: paronychia and pyogenic granuloma. J Am Acad Dermatol. 2011;64:AB37.
- Lipner SR, Scher RK. Onychomycosis: clinical overview and diagnosis. J Am Acad Dermatol. 2019;80:835-851.
- Kang R, Lipner S. Assessment of internet sources on subungual melanoma [published online August 30, 2018]. Melanoma Res. doi:10.1097/CMR.0000000000000508.
- Kang R, Lipner S. Evaluation of onychomycosis information on the internet. J Drugs Dermatol. 2019;18:484-487.
- Rieder EA, Tosti A. Cosmetically induced disorders of the nail with update on contemporary nail manicures. J Clin Aesthet Dermatol. 2016;9:39-44.
- Arias-Santiago S, Husein-ElAhmed H, Aneiros-Cachaza J, et al. Uncommon side effects of isotretinoin therapy: paronychia and pyogenic granuloma. J Am Acad Dermatol. 2011;64:AB37.
- Lipner SR, Scher RK. Onychomycosis: clinical overview and diagnosis. J Am Acad Dermatol. 2019;80:835-851.
Practice Points
- Patients often utilize online resources to research skin, hair, and nail conditions.
- Nail signs and symptoms may represent a serious underlying condition, and nail content is underrepresented on the American Academy of Dermatology (AAD) Patients and Public section of the website.
- There is a need for more information on nail conditions on the AAD website, offering patients a more comprehensive online dermatology resource. Subsequently, there has been a positive trend toward new nail content being added to the site.
New Insights Into the Dermatology Residency Application Process Amid the COVID-19 Pandemic
Residency application is an arduous experience for many medical students. The National Resident Matching Program reported that US medical school seniors who matched into dermatology applied to a median of 90 programs and attended 9 interviews in 2019.1 High application and interview travel costs are a disadvantage for applicants from lower socioeconomic backgrounds. We propose that the coronavirus disease 2019 (COVID-19) pandemic should serve as a call to action for dermatology to update and promote a more equitable, time-effective, and cost-efficient residency interview process.
In light of COVID-19, dermatology residency program directors have recommended a holistic application review process, taking into consideration “disparities in strength of applications due to lack of opportunity for students with smaller home programs or in areas more affected by this crisis.”2 However, in a 2018 survey of 180 dermatology faculty members, 80% stated that time spent reviewing residency applications was already excessive.3 The Association of American Medical Colleges reported that for medical student applicants with US Medical Licensing Examination Step 1 scores lower than 237 or higher than 251, the value added by submitting one additional application beyond means of 43 (95% confidence interval [CI], 34-53) and 34 (95% CI, 28-41), respectively, is reduced relative to the value added by each application before reaching the point of diminishing returns.4 Therefore, we suggest limiting the number of applications per applicant to the upper bounds of the CI for the lower US Medical Licensing Examination Step 1 score (53), facilitating a more detailed review of fewer applications by each program and limiting student expenses.
On May 7, 2020, the Association of American Medical Colleges made a statement strongly encouraging medical school and teaching hospital faculty to conduct interviews through videoconferencing.5 Videoconferencing interviews (VCIs) minimize travel-associated health risks, providing a more equitable structure for applicants and programs in areas disproportionately impacted by the pandemic. In the 2018 survey of dermatology faculty members, only 11% believed that applicants interviewing virtually received equal consideration to those interviewing in person; a solution to this problem would be to mandate that all applicants use VCIs during the COVID-19 pandemic.3 This coming year, residency programs may elect to replace in-person interviews with VCIs, or they may utilize VCIs as screening tools to narrow down the applicant pool and for students to rank their preferred programs prior to an in-person interview. By inviting fewer applicants for in-person interviews, travel-associated health risks, financial costs, and missed educational activities would be minimized. Given that many medical students have had academic activities cancelled or postponed due to COVID-19, student opportunities for live clinical experiences should be maximized.
As programs plan for future application cycles beyond COVID-19, they must work to balance competing interests. Videoconferencing interviews allow for improved access to interviewing for applicants of lower socioeconomic classes, improved geographic mobility of applicants, and increased flexibility in accommodating faculty schedules with reduced time away from patient care and research; however, with VCIs one may lose the personal element that comes from the in-person interview, including interactions among applicants, faculty, current residents, and staff on the day of interview, as well as the departmental tour. Additionally, the quality of VCIs may be diminished by technical difficulties and the possibility of distractions, making standardization of the interview experience for applicants challenging.
The COVID-19 pandemic will surely leave its mark on the residency application cycle. We must take time now to collaborate and brainstorm creative solutions to maximize the equity and efficiency of the application process for both residency programs and students. We welcome reader feedback on these ideas and other possible solutions in the form of Letters to the Editor.
- National Resident Matching Program. Results of the 2019 NRMP Applicant Survey by Preferred Specialty and Applicant Type. Washington, DC: National Resident Matching Program; 2019. https://mk0nrmp3oyqui6wqfm.kinstacdn.com/wp-content/uploads/2019/06/Applicant-Survey-Report-2019.pdf. Accessed June 22, 2020.
- Association of American Medical Colleges. Specialty response to COVID-19: dermatology residency program director consensus statement on 2020-21 application cycle. https://aamc-orange.global.ssl.fastly.net/production/media/filer_
public/0f/7b/0f7b547e-65b5-4d93-8247-951206e7f726/updated_dermatology_program_director_
statement_on_2020-21_application_cycle_.pdf. Updated June 1, 2020. Accessed June 24, 2020. - Rojek NW, Shinkai K, Fett N. Dermatology faculty and residents’ perspectives on the dermatology residency application process: a nationwide survey. J Am Acad Dermatol. 2018;79:157-159.
- Association of American Medical Colleges. Apply smart: data to consider when applying to residency. https://www.students-residents.aamc.org/applying-residency/filteredresult/apply-smart-data-consider-when-applying-residency/. Accessed June 22, 2020.
- Association of American Medical Colleges. Conducting interviews during the coronavirus pandemic. https://www.aamc.org/what-we-do/mission-areas/medical-education/conducting-interviews-during-coronavirus-pandemic/. Published May 7, 2020. Accessed June 22, 2020.
Residency application is an arduous experience for many medical students. The National Resident Matching Program reported that US medical school seniors who matched into dermatology applied to a median of 90 programs and attended 9 interviews in 2019.1 High application and interview travel costs are a disadvantage for applicants from lower socioeconomic backgrounds. We propose that the coronavirus disease 2019 (COVID-19) pandemic should serve as a call to action for dermatology to update and promote a more equitable, time-effective, and cost-efficient residency interview process.
In light of COVID-19, dermatology residency program directors have recommended a holistic application review process, taking into consideration “disparities in strength of applications due to lack of opportunity for students with smaller home programs or in areas more affected by this crisis.”2 However, in a 2018 survey of 180 dermatology faculty members, 80% stated that time spent reviewing residency applications was already excessive.3 The Association of American Medical Colleges reported that for medical student applicants with US Medical Licensing Examination Step 1 scores lower than 237 or higher than 251, the value added by submitting one additional application beyond means of 43 (95% confidence interval [CI], 34-53) and 34 (95% CI, 28-41), respectively, is reduced relative to the value added by each application before reaching the point of diminishing returns.4 Therefore, we suggest limiting the number of applications per applicant to the upper bounds of the CI for the lower US Medical Licensing Examination Step 1 score (53), facilitating a more detailed review of fewer applications by each program and limiting student expenses.
On May 7, 2020, the Association of American Medical Colleges made a statement strongly encouraging medical school and teaching hospital faculty to conduct interviews through videoconferencing.5 Videoconferencing interviews (VCIs) minimize travel-associated health risks, providing a more equitable structure for applicants and programs in areas disproportionately impacted by the pandemic. In the 2018 survey of dermatology faculty members, only 11% believed that applicants interviewing virtually received equal consideration to those interviewing in person; a solution to this problem would be to mandate that all applicants use VCIs during the COVID-19 pandemic.3 This coming year, residency programs may elect to replace in-person interviews with VCIs, or they may utilize VCIs as screening tools to narrow down the applicant pool and for students to rank their preferred programs prior to an in-person interview. By inviting fewer applicants for in-person interviews, travel-associated health risks, financial costs, and missed educational activities would be minimized. Given that many medical students have had academic activities cancelled or postponed due to COVID-19, student opportunities for live clinical experiences should be maximized.
As programs plan for future application cycles beyond COVID-19, they must work to balance competing interests. Videoconferencing interviews allow for improved access to interviewing for applicants of lower socioeconomic classes, improved geographic mobility of applicants, and increased flexibility in accommodating faculty schedules with reduced time away from patient care and research; however, with VCIs one may lose the personal element that comes from the in-person interview, including interactions among applicants, faculty, current residents, and staff on the day of interview, as well as the departmental tour. Additionally, the quality of VCIs may be diminished by technical difficulties and the possibility of distractions, making standardization of the interview experience for applicants challenging.
The COVID-19 pandemic will surely leave its mark on the residency application cycle. We must take time now to collaborate and brainstorm creative solutions to maximize the equity and efficiency of the application process for both residency programs and students. We welcome reader feedback on these ideas and other possible solutions in the form of Letters to the Editor.
Residency application is an arduous experience for many medical students. The National Resident Matching Program reported that US medical school seniors who matched into dermatology applied to a median of 90 programs and attended 9 interviews in 2019.1 High application and interview travel costs are a disadvantage for applicants from lower socioeconomic backgrounds. We propose that the coronavirus disease 2019 (COVID-19) pandemic should serve as a call to action for dermatology to update and promote a more equitable, time-effective, and cost-efficient residency interview process.
In light of COVID-19, dermatology residency program directors have recommended a holistic application review process, taking into consideration “disparities in strength of applications due to lack of opportunity for students with smaller home programs or in areas more affected by this crisis.”2 However, in a 2018 survey of 180 dermatology faculty members, 80% stated that time spent reviewing residency applications was already excessive.3 The Association of American Medical Colleges reported that for medical student applicants with US Medical Licensing Examination Step 1 scores lower than 237 or higher than 251, the value added by submitting one additional application beyond means of 43 (95% confidence interval [CI], 34-53) and 34 (95% CI, 28-41), respectively, is reduced relative to the value added by each application before reaching the point of diminishing returns.4 Therefore, we suggest limiting the number of applications per applicant to the upper bounds of the CI for the lower US Medical Licensing Examination Step 1 score (53), facilitating a more detailed review of fewer applications by each program and limiting student expenses.
On May 7, 2020, the Association of American Medical Colleges made a statement strongly encouraging medical school and teaching hospital faculty to conduct interviews through videoconferencing.5 Videoconferencing interviews (VCIs) minimize travel-associated health risks, providing a more equitable structure for applicants and programs in areas disproportionately impacted by the pandemic. In the 2018 survey of dermatology faculty members, only 11% believed that applicants interviewing virtually received equal consideration to those interviewing in person; a solution to this problem would be to mandate that all applicants use VCIs during the COVID-19 pandemic.3 This coming year, residency programs may elect to replace in-person interviews with VCIs, or they may utilize VCIs as screening tools to narrow down the applicant pool and for students to rank their preferred programs prior to an in-person interview. By inviting fewer applicants for in-person interviews, travel-associated health risks, financial costs, and missed educational activities would be minimized. Given that many medical students have had academic activities cancelled or postponed due to COVID-19, student opportunities for live clinical experiences should be maximized.
As programs plan for future application cycles beyond COVID-19, they must work to balance competing interests. Videoconferencing interviews allow for improved access to interviewing for applicants of lower socioeconomic classes, improved geographic mobility of applicants, and increased flexibility in accommodating faculty schedules with reduced time away from patient care and research; however, with VCIs one may lose the personal element that comes from the in-person interview, including interactions among applicants, faculty, current residents, and staff on the day of interview, as well as the departmental tour. Additionally, the quality of VCIs may be diminished by technical difficulties and the possibility of distractions, making standardization of the interview experience for applicants challenging.
The COVID-19 pandemic will surely leave its mark on the residency application cycle. We must take time now to collaborate and brainstorm creative solutions to maximize the equity and efficiency of the application process for both residency programs and students. We welcome reader feedback on these ideas and other possible solutions in the form of Letters to the Editor.
- National Resident Matching Program. Results of the 2019 NRMP Applicant Survey by Preferred Specialty and Applicant Type. Washington, DC: National Resident Matching Program; 2019. https://mk0nrmp3oyqui6wqfm.kinstacdn.com/wp-content/uploads/2019/06/Applicant-Survey-Report-2019.pdf. Accessed June 22, 2020.
- Association of American Medical Colleges. Specialty response to COVID-19: dermatology residency program director consensus statement on 2020-21 application cycle. https://aamc-orange.global.ssl.fastly.net/production/media/filer_
public/0f/7b/0f7b547e-65b5-4d93-8247-951206e7f726/updated_dermatology_program_director_
statement_on_2020-21_application_cycle_.pdf. Updated June 1, 2020. Accessed June 24, 2020. - Rojek NW, Shinkai K, Fett N. Dermatology faculty and residents’ perspectives on the dermatology residency application process: a nationwide survey. J Am Acad Dermatol. 2018;79:157-159.
- Association of American Medical Colleges. Apply smart: data to consider when applying to residency. https://www.students-residents.aamc.org/applying-residency/filteredresult/apply-smart-data-consider-when-applying-residency/. Accessed June 22, 2020.
- Association of American Medical Colleges. Conducting interviews during the coronavirus pandemic. https://www.aamc.org/what-we-do/mission-areas/medical-education/conducting-interviews-during-coronavirus-pandemic/. Published May 7, 2020. Accessed June 22, 2020.
- National Resident Matching Program. Results of the 2019 NRMP Applicant Survey by Preferred Specialty and Applicant Type. Washington, DC: National Resident Matching Program; 2019. https://mk0nrmp3oyqui6wqfm.kinstacdn.com/wp-content/uploads/2019/06/Applicant-Survey-Report-2019.pdf. Accessed June 22, 2020.
- Association of American Medical Colleges. Specialty response to COVID-19: dermatology residency program director consensus statement on 2020-21 application cycle. https://aamc-orange.global.ssl.fastly.net/production/media/filer_
public/0f/7b/0f7b547e-65b5-4d93-8247-951206e7f726/updated_dermatology_program_director_
statement_on_2020-21_application_cycle_.pdf. Updated June 1, 2020. Accessed June 24, 2020. - Rojek NW, Shinkai K, Fett N. Dermatology faculty and residents’ perspectives on the dermatology residency application process: a nationwide survey. J Am Acad Dermatol. 2018;79:157-159.
- Association of American Medical Colleges. Apply smart: data to consider when applying to residency. https://www.students-residents.aamc.org/applying-residency/filteredresult/apply-smart-data-consider-when-applying-residency/. Accessed June 22, 2020.
- Association of American Medical Colleges. Conducting interviews during the coronavirus pandemic. https://www.aamc.org/what-we-do/mission-areas/medical-education/conducting-interviews-during-coronavirus-pandemic/. Published May 7, 2020. Accessed June 22, 2020.
Practice Points
- We propose that the coronavirus disease 2019 pandemic should serve as a call to action for dermatology to update and promote a more equitable, time-effective, and cost-efficient residency interview process.
- A limitation on the number of applications per candidate may lower expenses and allow for a more holistic review process by residency programs.
- The benefits and challenges of videoconferencing interviews must be weighed as residency programs decide on their continued use beyond this application cycle.
Brilliant Green Staining of the Fingernails
Case Report
A 92-year-old Eastern European woman presented to our nail clinic with a history of onychodystrophy and arthralgia of the digits of several months’ duration. Her dermatologic history was notable for irritant hand dermatitis. A prior nail plate clipping with histopathologic examination was negative for fungal elements. Physical examination revealed onychorrhexis of all fingernails as well as onycholysis and subungual hyperkeratosis of the right fourth fingernail. Blue-green staining was incidentally noted on the right second and third fingernails and nail folds (Figure 1). Contact dermoscopy using ultrasound gel revealed translucent areas with sparse pigment, though denser areas had a fine branching pattern (Figure 2). When questioned, the patient reported use of “zelyonka,” a brilliant green solution, to self-treat the nails. Histopathology on repeat nail clippings showed parakeratosis and serum, which was most consistent with her known history of irritant hand dermatitis. Radiographs of the hands revealed osteoarthritis that was most prominent at the distal interphalangeal joints.


Comment
Brilliant green is a triphenylmethane dye commonly used in Eastern Europe and other regions for the treatment of superficial skin infections and onychomycosis.1 Its use as an antiseptic and wound healing agent has been investigated in the scientific literature since at least the early 20th century.2 Brilliant green typically is applied in a 0.1% to 2% ethanol solution.1 The dye has bactericidal activity against gram-positive organisms, particularly staphylococci and streptococci.2,3 It has been used for the treatment of fungal skin and nail infections since at least the early 20th century, with anecdotal success.4 Although there have been no studies investigating use of brilliant green alone for the treatment of onychomycosis, it is sometimes used in combination with conventional oral agents for this purpose.5 Because of its availability, safety, ease of use, and low cost, brilliant green has been promoted as an antiseptic in resource-poor settings.3 The revival of brilliant green and other antiseptic dyes in these settings has been suggested as an alternative to oral antibiotic agents, to which resistance is rising, and as a potential cancer therapy.6,7 Although brilliant green’s mechanism of action in treating skin infections is unclear, it has been shown to form covalent adducts with thioredoxin reductase 2, a protein conserved from bacteria to humans with an essential function for cellular activity.7
Early case studies suggested that brilliant green was beneficial in treating wounds2; however, this indication is controversial. In a guinea pig study, brilliant green was shown to inhibit wound healing and the formation of granulation tissue.8 It also should be noted that when used topically, brilliant green may cause skin sensitization, necrotic skin reactions, and permanent staining of clothing. It has no known anti-inflammatory properties and also may cause skin irritation.8 Brilliant green may cause blindness if it comes in contact with the eyes.1
Brilliant green has other potential dermatologic indications. For example, a combination of brilliant green and gentian violet, a related dye, has demonstrated efficacy in the treatment of cutaneous hemangiomas in mouse models by blocking expression of angiopoietin-2.7
Dermatologists should be familiar with brilliant green and its common uses as well as adverse effects. Brilliant green is commercially available for a low cost ($5 to $20) in specialty pharmacies or online (eg, Amazon). It is sold alone or in combination with gentian violet and proflavine hemisulfate, and a prescription is not required. Due to its low cost and accessibility, patients may use brilliant green to self-treat dermatologic conditions. Green nails due to staining with brilliant green dye must be distinguished from other etiologies causing green nail discoloration, such as infection with Pseudomonas aeruginosa or Aspergillus, bullous disorders, jaundice, “old” hematomas, nail polish, and other exogenous pigments.
- Balabanova M, Popova L, Tchipeva R. Dyes in dermatology. Clin Dermatol. 2003;21:2-6.
- Browning CH, Gulbransen R, Kennaway EL, et al. Flavine and brilliant green, powerful antiseptics with low toxicity to the tissues: their use in the treatment of infected wounds. Br Med J. 1917;1:73-78.
- Bakker P, Doorne H, Gooskens V, et al. Activity of gentian violet and brilliant green against some microorganisms associated with skin infections. Int J Dermatol. 1992;31:210-213.
- Montgomery RM, Casper EA. Cutaneous manifestations of the fungi causing dermatophytosis and onychomycosis and their treatment. J Am Med Assoc. 1945;128:77-83.
- Tchernev G, Cardoso JC, Ali MM, et al. Primary onychomycosis with granulomatous Tinea faciei. Braz J Infect Dis. 2010;14:546-547.
- Berrios RL, Arbiser JL. Effectiveness of gentian violet and similar products commonly used to treat pyodermas. Dermatol Clin. 2011;29:69-73.
- Maley AM, Arbiser JL. Gentian violet: a 19th century drug re-emerges in the 21st century. Exp Dermatol. 2013;22:775-80.
- Niedner R, Schöpf E. Inhibition of wound healing by antiseptics. Br J Dermatol. 1986;115:41-44
Case Report
A 92-year-old Eastern European woman presented to our nail clinic with a history of onychodystrophy and arthralgia of the digits of several months’ duration. Her dermatologic history was notable for irritant hand dermatitis. A prior nail plate clipping with histopathologic examination was negative for fungal elements. Physical examination revealed onychorrhexis of all fingernails as well as onycholysis and subungual hyperkeratosis of the right fourth fingernail. Blue-green staining was incidentally noted on the right second and third fingernails and nail folds (Figure 1). Contact dermoscopy using ultrasound gel revealed translucent areas with sparse pigment, though denser areas had a fine branching pattern (Figure 2). When questioned, the patient reported use of “zelyonka,” a brilliant green solution, to self-treat the nails. Histopathology on repeat nail clippings showed parakeratosis and serum, which was most consistent with her known history of irritant hand dermatitis. Radiographs of the hands revealed osteoarthritis that was most prominent at the distal interphalangeal joints.


Comment
Brilliant green is a triphenylmethane dye commonly used in Eastern Europe and other regions for the treatment of superficial skin infections and onychomycosis.1 Its use as an antiseptic and wound healing agent has been investigated in the scientific literature since at least the early 20th century.2 Brilliant green typically is applied in a 0.1% to 2% ethanol solution.1 The dye has bactericidal activity against gram-positive organisms, particularly staphylococci and streptococci.2,3 It has been used for the treatment of fungal skin and nail infections since at least the early 20th century, with anecdotal success.4 Although there have been no studies investigating use of brilliant green alone for the treatment of onychomycosis, it is sometimes used in combination with conventional oral agents for this purpose.5 Because of its availability, safety, ease of use, and low cost, brilliant green has been promoted as an antiseptic in resource-poor settings.3 The revival of brilliant green and other antiseptic dyes in these settings has been suggested as an alternative to oral antibiotic agents, to which resistance is rising, and as a potential cancer therapy.6,7 Although brilliant green’s mechanism of action in treating skin infections is unclear, it has been shown to form covalent adducts with thioredoxin reductase 2, a protein conserved from bacteria to humans with an essential function for cellular activity.7
Early case studies suggested that brilliant green was beneficial in treating wounds2; however, this indication is controversial. In a guinea pig study, brilliant green was shown to inhibit wound healing and the formation of granulation tissue.8 It also should be noted that when used topically, brilliant green may cause skin sensitization, necrotic skin reactions, and permanent staining of clothing. It has no known anti-inflammatory properties and also may cause skin irritation.8 Brilliant green may cause blindness if it comes in contact with the eyes.1
Brilliant green has other potential dermatologic indications. For example, a combination of brilliant green and gentian violet, a related dye, has demonstrated efficacy in the treatment of cutaneous hemangiomas in mouse models by blocking expression of angiopoietin-2.7
Dermatologists should be familiar with brilliant green and its common uses as well as adverse effects. Brilliant green is commercially available for a low cost ($5 to $20) in specialty pharmacies or online (eg, Amazon). It is sold alone or in combination with gentian violet and proflavine hemisulfate, and a prescription is not required. Due to its low cost and accessibility, patients may use brilliant green to self-treat dermatologic conditions. Green nails due to staining with brilliant green dye must be distinguished from other etiologies causing green nail discoloration, such as infection with Pseudomonas aeruginosa or Aspergillus, bullous disorders, jaundice, “old” hematomas, nail polish, and other exogenous pigments.
Case Report
A 92-year-old Eastern European woman presented to our nail clinic with a history of onychodystrophy and arthralgia of the digits of several months’ duration. Her dermatologic history was notable for irritant hand dermatitis. A prior nail plate clipping with histopathologic examination was negative for fungal elements. Physical examination revealed onychorrhexis of all fingernails as well as onycholysis and subungual hyperkeratosis of the right fourth fingernail. Blue-green staining was incidentally noted on the right second and third fingernails and nail folds (Figure 1). Contact dermoscopy using ultrasound gel revealed translucent areas with sparse pigment, though denser areas had a fine branching pattern (Figure 2). When questioned, the patient reported use of “zelyonka,” a brilliant green solution, to self-treat the nails. Histopathology on repeat nail clippings showed parakeratosis and serum, which was most consistent with her known history of irritant hand dermatitis. Radiographs of the hands revealed osteoarthritis that was most prominent at the distal interphalangeal joints.


Comment
Brilliant green is a triphenylmethane dye commonly used in Eastern Europe and other regions for the treatment of superficial skin infections and onychomycosis.1 Its use as an antiseptic and wound healing agent has been investigated in the scientific literature since at least the early 20th century.2 Brilliant green typically is applied in a 0.1% to 2% ethanol solution.1 The dye has bactericidal activity against gram-positive organisms, particularly staphylococci and streptococci.2,3 It has been used for the treatment of fungal skin and nail infections since at least the early 20th century, with anecdotal success.4 Although there have been no studies investigating use of brilliant green alone for the treatment of onychomycosis, it is sometimes used in combination with conventional oral agents for this purpose.5 Because of its availability, safety, ease of use, and low cost, brilliant green has been promoted as an antiseptic in resource-poor settings.3 The revival of brilliant green and other antiseptic dyes in these settings has been suggested as an alternative to oral antibiotic agents, to which resistance is rising, and as a potential cancer therapy.6,7 Although brilliant green’s mechanism of action in treating skin infections is unclear, it has been shown to form covalent adducts with thioredoxin reductase 2, a protein conserved from bacteria to humans with an essential function for cellular activity.7
Early case studies suggested that brilliant green was beneficial in treating wounds2; however, this indication is controversial. In a guinea pig study, brilliant green was shown to inhibit wound healing and the formation of granulation tissue.8 It also should be noted that when used topically, brilliant green may cause skin sensitization, necrotic skin reactions, and permanent staining of clothing. It has no known anti-inflammatory properties and also may cause skin irritation.8 Brilliant green may cause blindness if it comes in contact with the eyes.1
Brilliant green has other potential dermatologic indications. For example, a combination of brilliant green and gentian violet, a related dye, has demonstrated efficacy in the treatment of cutaneous hemangiomas in mouse models by blocking expression of angiopoietin-2.7
Dermatologists should be familiar with brilliant green and its common uses as well as adverse effects. Brilliant green is commercially available for a low cost ($5 to $20) in specialty pharmacies or online (eg, Amazon). It is sold alone or in combination with gentian violet and proflavine hemisulfate, and a prescription is not required. Due to its low cost and accessibility, patients may use brilliant green to self-treat dermatologic conditions. Green nails due to staining with brilliant green dye must be distinguished from other etiologies causing green nail discoloration, such as infection with Pseudomonas aeruginosa or Aspergillus, bullous disorders, jaundice, “old” hematomas, nail polish, and other exogenous pigments.
- Balabanova M, Popova L, Tchipeva R. Dyes in dermatology. Clin Dermatol. 2003;21:2-6.
- Browning CH, Gulbransen R, Kennaway EL, et al. Flavine and brilliant green, powerful antiseptics with low toxicity to the tissues: their use in the treatment of infected wounds. Br Med J. 1917;1:73-78.
- Bakker P, Doorne H, Gooskens V, et al. Activity of gentian violet and brilliant green against some microorganisms associated with skin infections. Int J Dermatol. 1992;31:210-213.
- Montgomery RM, Casper EA. Cutaneous manifestations of the fungi causing dermatophytosis and onychomycosis and their treatment. J Am Med Assoc. 1945;128:77-83.
- Tchernev G, Cardoso JC, Ali MM, et al. Primary onychomycosis with granulomatous Tinea faciei. Braz J Infect Dis. 2010;14:546-547.
- Berrios RL, Arbiser JL. Effectiveness of gentian violet and similar products commonly used to treat pyodermas. Dermatol Clin. 2011;29:69-73.
- Maley AM, Arbiser JL. Gentian violet: a 19th century drug re-emerges in the 21st century. Exp Dermatol. 2013;22:775-80.
- Niedner R, Schöpf E. Inhibition of wound healing by antiseptics. Br J Dermatol. 1986;115:41-44
- Balabanova M, Popova L, Tchipeva R. Dyes in dermatology. Clin Dermatol. 2003;21:2-6.
- Browning CH, Gulbransen R, Kennaway EL, et al. Flavine and brilliant green, powerful antiseptics with low toxicity to the tissues: their use in the treatment of infected wounds. Br Med J. 1917;1:73-78.
- Bakker P, Doorne H, Gooskens V, et al. Activity of gentian violet and brilliant green against some microorganisms associated with skin infections. Int J Dermatol. 1992;31:210-213.
- Montgomery RM, Casper EA. Cutaneous manifestations of the fungi causing dermatophytosis and onychomycosis and their treatment. J Am Med Assoc. 1945;128:77-83.
- Tchernev G, Cardoso JC, Ali MM, et al. Primary onychomycosis with granulomatous Tinea faciei. Braz J Infect Dis. 2010;14:546-547.
- Berrios RL, Arbiser JL. Effectiveness of gentian violet and similar products commonly used to treat pyodermas. Dermatol Clin. 2011;29:69-73.
- Maley AM, Arbiser JL. Gentian violet: a 19th century drug re-emerges in the 21st century. Exp Dermatol. 2013;22:775-80.
- Niedner R, Schöpf E. Inhibition of wound healing by antiseptics. Br J Dermatol. 1986;115:41-44
Practice Points
- Chloronychia, or green nail syndrome, is due to Pseudomonas aeruginosaPalatino LT Std infection and is a common etiology of green nail discoloration. Green nail discoloration also may be secondary to use of the antiseptic dye brilliant green.
- Brilliant green is bactericidal but has no known antifungal or anti-inflammatory activity; it should be considered in the differential diagnosis of green nail discoloration and also may cause blindness with eye contact.
Utilization of a Stress Ball to Diminish Anxiety During Nail Surgery
Practice Gap
Anxiety is common in patients undergoing surgery with general anesthesia and may be exacerbated in patients undergoing dermatologic surgery with local anesthesia. Apprehension might be worse for nail surgery patients because the nail unit is highly innervated and vascular. Many patients fear the anesthetic injections, and there often is pain postoperatively. Perioperative anxiety correlates with increased postoperative pain,1 analgesic use,2 and delayed recovery.3 Several alternatives have been proposed to decrease perioperative anxiety, including nonpharmacologic interventions such as using educational videos, personalized music, hand holding, art activities, and virtual reality, as well as pharmacologic interventions such as benzodiazepines. However, these techniques have not been well studied for nail surgery.
The Technique
Patients generally are anxious about nail surgery secondary to the pain associated with the local anesthetic infiltration; hence, it is crucial to decrease anxiety during this initial step. In our practice, we provide patients with a palm-sized stress ball made of closed-cell polyurethane foam rubber before surgery. Patients are then instructed to hold the stress ball with the free hand and squeeze it whenever they feel anxious or when they feel any discomfort related to the procedure (Figure). A variety of balls can be bought for less than $1 each, thus making it a cost-effective option.

Practice Implications
Holding a stress ball has been found to reduce both pain and anxiety in patients undergoing conscious surgery.4 Furthermore, squeezing a stress ball perioperatively may increase feelings of empowerment, given that patients have direct control over the object, which in turn may have a positive effect on anxiety and patient satisfaction without interfering with the surgical procedure.5 Holding a stress ball is a safe, widely accessible, and inexpensive technique that may aid in decreasing patients’ anxiety related to nail surgery. Nonetheless, controlled clinical trials assessing the efficacy of this method in reducing anxiety related to nail surgery are needed to determine its benefit compared to other methods.
- Carr EC, Nicky Thomas V, Wilson-Barnet J. Patient experiences of anxiety, depression and acute pain after surgery: a longitudinal perspective. Int J Nurs Stud. 2005;42:521-530.
- Powell R, Johnston M, Smith WC, et al. Psychological risk factors for chronic post-surgical pain after inguinal hernia repair surgery: a prospective cohort study. Eur J Pain. 2012;16:600-610.
- Mavros MN, Athanasiou S, Gkegkes ID, et al. Do psychological variables affect early surgical recovery? PLoS One. 2011;6:e20306.
- Hudson BF, Ogden J, Whiteley MS. Randomized controlled trial to compare the effect of simple distraction interventions on pain and anxiety experienced during conscious surgery. Eur J Pain. 2015;19:1447-1455.
- Foy CR, Timmins F. Improving communication in day surgery settings. Nurs Stand. 2004;19:37-42.
Practice Gap
Anxiety is common in patients undergoing surgery with general anesthesia and may be exacerbated in patients undergoing dermatologic surgery with local anesthesia. Apprehension might be worse for nail surgery patients because the nail unit is highly innervated and vascular. Many patients fear the anesthetic injections, and there often is pain postoperatively. Perioperative anxiety correlates with increased postoperative pain,1 analgesic use,2 and delayed recovery.3 Several alternatives have been proposed to decrease perioperative anxiety, including nonpharmacologic interventions such as using educational videos, personalized music, hand holding, art activities, and virtual reality, as well as pharmacologic interventions such as benzodiazepines. However, these techniques have not been well studied for nail surgery.
The Technique
Patients generally are anxious about nail surgery secondary to the pain associated with the local anesthetic infiltration; hence, it is crucial to decrease anxiety during this initial step. In our practice, we provide patients with a palm-sized stress ball made of closed-cell polyurethane foam rubber before surgery. Patients are then instructed to hold the stress ball with the free hand and squeeze it whenever they feel anxious or when they feel any discomfort related to the procedure (Figure). A variety of balls can be bought for less than $1 each, thus making it a cost-effective option.

Practice Implications
Holding a stress ball has been found to reduce both pain and anxiety in patients undergoing conscious surgery.4 Furthermore, squeezing a stress ball perioperatively may increase feelings of empowerment, given that patients have direct control over the object, which in turn may have a positive effect on anxiety and patient satisfaction without interfering with the surgical procedure.5 Holding a stress ball is a safe, widely accessible, and inexpensive technique that may aid in decreasing patients’ anxiety related to nail surgery. Nonetheless, controlled clinical trials assessing the efficacy of this method in reducing anxiety related to nail surgery are needed to determine its benefit compared to other methods.
Practice Gap
Anxiety is common in patients undergoing surgery with general anesthesia and may be exacerbated in patients undergoing dermatologic surgery with local anesthesia. Apprehension might be worse for nail surgery patients because the nail unit is highly innervated and vascular. Many patients fear the anesthetic injections, and there often is pain postoperatively. Perioperative anxiety correlates with increased postoperative pain,1 analgesic use,2 and delayed recovery.3 Several alternatives have been proposed to decrease perioperative anxiety, including nonpharmacologic interventions such as using educational videos, personalized music, hand holding, art activities, and virtual reality, as well as pharmacologic interventions such as benzodiazepines. However, these techniques have not been well studied for nail surgery.
The Technique
Patients generally are anxious about nail surgery secondary to the pain associated with the local anesthetic infiltration; hence, it is crucial to decrease anxiety during this initial step. In our practice, we provide patients with a palm-sized stress ball made of closed-cell polyurethane foam rubber before surgery. Patients are then instructed to hold the stress ball with the free hand and squeeze it whenever they feel anxious or when they feel any discomfort related to the procedure (Figure). A variety of balls can be bought for less than $1 each, thus making it a cost-effective option.

Practice Implications
Holding a stress ball has been found to reduce both pain and anxiety in patients undergoing conscious surgery.4 Furthermore, squeezing a stress ball perioperatively may increase feelings of empowerment, given that patients have direct control over the object, which in turn may have a positive effect on anxiety and patient satisfaction without interfering with the surgical procedure.5 Holding a stress ball is a safe, widely accessible, and inexpensive technique that may aid in decreasing patients’ anxiety related to nail surgery. Nonetheless, controlled clinical trials assessing the efficacy of this method in reducing anxiety related to nail surgery are needed to determine its benefit compared to other methods.
- Carr EC, Nicky Thomas V, Wilson-Barnet J. Patient experiences of anxiety, depression and acute pain after surgery: a longitudinal perspective. Int J Nurs Stud. 2005;42:521-530.
- Powell R, Johnston M, Smith WC, et al. Psychological risk factors for chronic post-surgical pain after inguinal hernia repair surgery: a prospective cohort study. Eur J Pain. 2012;16:600-610.
- Mavros MN, Athanasiou S, Gkegkes ID, et al. Do psychological variables affect early surgical recovery? PLoS One. 2011;6:e20306.
- Hudson BF, Ogden J, Whiteley MS. Randomized controlled trial to compare the effect of simple distraction interventions on pain and anxiety experienced during conscious surgery. Eur J Pain. 2015;19:1447-1455.
- Foy CR, Timmins F. Improving communication in day surgery settings. Nurs Stand. 2004;19:37-42.
- Carr EC, Nicky Thomas V, Wilson-Barnet J. Patient experiences of anxiety, depression and acute pain after surgery: a longitudinal perspective. Int J Nurs Stud. 2005;42:521-530.
- Powell R, Johnston M, Smith WC, et al. Psychological risk factors for chronic post-surgical pain after inguinal hernia repair surgery: a prospective cohort study. Eur J Pain. 2012;16:600-610.
- Mavros MN, Athanasiou S, Gkegkes ID, et al. Do psychological variables affect early surgical recovery? PLoS One. 2011;6:e20306.
- Hudson BF, Ogden J, Whiteley MS. Randomized controlled trial to compare the effect of simple distraction interventions on pain and anxiety experienced during conscious surgery. Eur J Pain. 2015;19:1447-1455.
- Foy CR, Timmins F. Improving communication in day surgery settings. Nurs Stand. 2004;19:37-42.
Hand Hygiene in Preventing COVID-19 Transmission
Handwashing with antimicrobial soaps or alcohol-based sanitizers is an effective measure in preventing microbial disease transmission. In the context of coronavirus disease 2019 (COVID-19) prevention, the World Health Organization and Centers for Disease Control and Prevention have recommended handwashing with soap and water after coughing/sneezing, visiting a public place, touching surfaces outside the home, and taking care of a sick person(s), as well as before and after eating. When soap and water are not available, alcohol-based sanitizers may be used.1,2
Irritant contact dermatitis (ICD) is most commonly associated with wet work and is frequently seen in health care workers in relation to hand hygiene, with survey-based studies reporting 25% to 55% of nurses affected.3-5 In a prospective study (N=102), health care workers who washed their hands more than 10 times per day were55% more likely to develop hand dermatitis.6 Frequent ICD of the hands has been reported in Chinese health care workers in association with COVID-19.7 Handwashing and/or glove wearing may be newly prioritized by workers who handle frequently touched goods and surfaces, such as flight attendants (Figure). Patients with obsessive-compulsive disorder may be another vulnerable population.8

Alcohol-based sanitizers and detergents or antimicrobials in soaps may cause ICD of the hands by denaturation of stratum corneum proteins, depletion of intercellular lipids, and decreased corneocyte cohesion. These agents alter the skin flora, with increased colonization by staphylococci and gram-negative bacilli.9 Clinical findings include xerosis, scaling, fissuring, and bleeding. Physicians may evaluate severity of ICD of the hands using the
Cleansing the hands with alcohol-based sanitizers has consistently shown equivalent or greater efficacy than antimicrobial soaps for eradication of most microbes, with exception of bacterial spores and protozoan oocysts.11 In an in vivo experiment, 70% ethanol solution was more effective in eradicating rotavirus from the fingerpads of adults than 10% povidone-iodine solution, nonmedicated soaps, and soaps containing chloroxylenol 4.8% or chlorhexidine gluconate 4%.12 Coronavirus disease 2019 is a lipophilic enveloped virus. The lipid-dissolving effects of alcohol-based sanitizers is especially effective against these kinds of viruses. An in vitro experiment showed that alcohol solutions are effective against enveloped viruses including severe acute respiratory syndrome coronavirus, Ebola virus, and Zika virus.13 There are limited data for the virucidal efficacy of non–alcohol-based sanitizers containing quaternary ammonium compounds (most commonly benzalkonium chloride) and therefore they are not recommended for protection against COVID-19. Handwashing is preferred over alcohol-based solutions when hands are visibly dirty.
Alcohol-based sanitizers typically are less likely to cause ICD than handwashing with detergent-based or antimicrobial soaps. Antimicrobial ingredients in soaps such as chlorhexidine, chloroxylenol, and triclosan are frequent culprits.11 Detergents in soap such as sodium laureth sulfate cause more skin irritation and transepidermal water loss than alcohol14; however, among health care workers, alcohol-based sanitizers often are perceived as more damaging to the skin.15 During the 2014 Ebola outbreak, use of alcohol-based sanitizers vs handwashing resulted in lower hand eczema severity index scores (n=108).16
Propensity for ICD is a limiting factor in hand hygiene adherence.17 In a double-blind randomized trial (N=54), scheduled use of an oil-containing lotion was shown to increase compliance with hand hygiene protocols in health care workers by preventing cracks, scaling, and pain.18 Using sanitizers containing humectants (eg, aloe vera gel) or moisturizers with petrolatum, liquid paraffin, glycerin, or mineral oil have all been shown to decrease the incidence of ICD in frequent handwashers.19,20 Thorough hand drying also is important in preventing dermatitis. Drying with disposable paper towels is preferred over automated air dryers to prevent aerosolization of microbes.21 Because latex has been implicated in development of ICD, use of latex-free gloves is recommended.22
Alcohol-based sanitizer is not only an effective virucidal agent but also is less likely to cause ICD, therefore promoting hand hygiene adherence. Handwashing with soap still is necessary when hands are visibly dirty but should be performed less frequently if feasible. Hand hygiene and emollient usage education is important for physicians and patients alike, particularly during the COVID-19 crisis.
- Centers for Disease Control and Prevention. Coronavirus disease 2019. how to protect yourself & others. https://www.cdc.gov/coronavirus/2019-ncov/prepare/prevention.html. Updated April 13, 2020. Accessed April 21, 2020.
- World Health Organization. Coronavirus disease (COVID-19) advice for the public. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public. Updated March 31, 2020. Accessed April 21, 2020.
- Carøe TK, Ebbehøj NE, Bonde JPE, et al. Hand eczema and wet work: dose-response relationship and effect of leaving the profession. Contact Dermatitis. 2018;78:341-347.
- Larson E, Friedman C, Cohran J, et al. Prevalence and correlates of skin damage on the hands of nurses. Heart Lung. 1997;26:404-412.
- Lampel HP, Patel N, Boyse K, et al. Prevalence of hand dermatitis in inpatient nurses at a United States hospital. Dermatitis. 2007;18:140-142.
- Callahan A, Baron E, Fekedulegn D, et al. Winter season, frequent hand washing, and irritant patch test reactions to detergents are associated with hand dermatitis in health care workers. Dermatitis. 2013;24:170-175.
- Lan J, Song Z, Miao X, et al. Skin damage among healthcare workers managing coronavirus disease-2019 [published online March 18, 2020]. J Am Acad Dermatol. 2020;82:1215-1216.
- Katz RJ, Landau P, DeVeaugh-Geiss J, et al. Pharmacological responsiveness of dermatitis secondary to compulsive washing. Psychiatry Res. 1990;34:223-226.
- Larson EL, Hughes CA, Pyrek JD, et al. Changes in bacterial flora associated with skin damage on hands of health care personnel. Am J Infect Control. 1998;26:513-521.
- Held E, Skoet R, Johansen JD, et al. The hand eczema severity index (HECSI): a scoring system for clinical assessment of hand eczema. a study of inter- and intraobserver reliability. Br J Dermatol. 2005;152:302-307.
- Boyce JM, Pittet D, Healthcare Infection Control Practices Advisory Committee, et al. Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HIPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Am J Infect Control. 2002;30:S1-S46.
- Ansari SA, Sattar SA, Springthorpe VS, et al. Invivo protocol for testing efficacy of hand-washing agents against viruses and bacteria—experiments with rotavirus and Escherichi coli. Appl Environ Microbiol. 1989;55:3113-3118.
- Siddharta A, Pfaender S, Vielle NJ, et al. virucidal activity of world health organization-recommended formulations against enveloped viruses, including Zika, Ebola, and emerging coronaviruses. J Infect Dis. 2017;215:902-906.
- Pedersen LK, Held E, Johansen JD, et al. Less skin irritation from alcohol-based disinfectant than from detergent used for hand disinfection. Br J Dermatol. 2005;153:1142-1146.
- Stutz N, Becker D, Jappe U, et al. Nurses’ perceptions of the benefits and adverse effects of hand disinfection: alcohol-based hand rubs vs. hygienic handwashing: a multicentre questionnaire study with additional patch testing by the German Contact Dermatitis Research Group. Br J Dermatol. 2009;160:565-572.
- Wolfe MK, Wells E, Mitro B, et al. Seeking clearer recommendations for hand hygiene in communities facing Ebola: a randomized trial investigating the impact of six handwashing methods on skin irritation and dermatitis. PLoS One. 2016;11:e0167378.
- Pittet D, Allegranzi B, Storr J. The WHO Clean Care is Safer Care programme: field-testing to enhance sustainability and spread of hand hygiene improvements. J Infect Public Health. 2008;1:4-10.
- McCormick RD, Buchman TL, Maki DG. Double-blind, randomized trial of scheduled use of a novel barrier cream and an oil-containing lotion for protecting the hands of health care workers. Am J Infect Control. 2000;28:302-310.
- Berndt U, Wigger-Alberti W, Gabard B, et al. Efficacy of a barrier cream and its vehicle as protective measures against occupational irritant contact dermatitis. Contact Dermatitis. 2000;42:77-80.
- Kampf G, Ennen J. Regular use of a hand cream can attenuate skin dryness and roughness caused by frequent hand washing. BMC Dermatol. 2006;6:1.
- Gammon J, Hunt J. The neglected element of hand hygiene - significance of hand drying, efficiency of different methods, and clinical implication: a review. J Infect Prev. 2019;20:66-74.
- Elston DM. Letter from the editor: occupational skin disease among healthcare workers during the coronavirus (COVID-19) epidemic [published online March 18, 2020]. J Am Acad Dermatol. 2020;82:1085-1086.
Handwashing with antimicrobial soaps or alcohol-based sanitizers is an effective measure in preventing microbial disease transmission. In the context of coronavirus disease 2019 (COVID-19) prevention, the World Health Organization and Centers for Disease Control and Prevention have recommended handwashing with soap and water after coughing/sneezing, visiting a public place, touching surfaces outside the home, and taking care of a sick person(s), as well as before and after eating. When soap and water are not available, alcohol-based sanitizers may be used.1,2
Irritant contact dermatitis (ICD) is most commonly associated with wet work and is frequently seen in health care workers in relation to hand hygiene, with survey-based studies reporting 25% to 55% of nurses affected.3-5 In a prospective study (N=102), health care workers who washed their hands more than 10 times per day were55% more likely to develop hand dermatitis.6 Frequent ICD of the hands has been reported in Chinese health care workers in association with COVID-19.7 Handwashing and/or glove wearing may be newly prioritized by workers who handle frequently touched goods and surfaces, such as flight attendants (Figure). Patients with obsessive-compulsive disorder may be another vulnerable population.8

Alcohol-based sanitizers and detergents or antimicrobials in soaps may cause ICD of the hands by denaturation of stratum corneum proteins, depletion of intercellular lipids, and decreased corneocyte cohesion. These agents alter the skin flora, with increased colonization by staphylococci and gram-negative bacilli.9 Clinical findings include xerosis, scaling, fissuring, and bleeding. Physicians may evaluate severity of ICD of the hands using the
Cleansing the hands with alcohol-based sanitizers has consistently shown equivalent or greater efficacy than antimicrobial soaps for eradication of most microbes, with exception of bacterial spores and protozoan oocysts.11 In an in vivo experiment, 70% ethanol solution was more effective in eradicating rotavirus from the fingerpads of adults than 10% povidone-iodine solution, nonmedicated soaps, and soaps containing chloroxylenol 4.8% or chlorhexidine gluconate 4%.12 Coronavirus disease 2019 is a lipophilic enveloped virus. The lipid-dissolving effects of alcohol-based sanitizers is especially effective against these kinds of viruses. An in vitro experiment showed that alcohol solutions are effective against enveloped viruses including severe acute respiratory syndrome coronavirus, Ebola virus, and Zika virus.13 There are limited data for the virucidal efficacy of non–alcohol-based sanitizers containing quaternary ammonium compounds (most commonly benzalkonium chloride) and therefore they are not recommended for protection against COVID-19. Handwashing is preferred over alcohol-based solutions when hands are visibly dirty.
Alcohol-based sanitizers typically are less likely to cause ICD than handwashing with detergent-based or antimicrobial soaps. Antimicrobial ingredients in soaps such as chlorhexidine, chloroxylenol, and triclosan are frequent culprits.11 Detergents in soap such as sodium laureth sulfate cause more skin irritation and transepidermal water loss than alcohol14; however, among health care workers, alcohol-based sanitizers often are perceived as more damaging to the skin.15 During the 2014 Ebola outbreak, use of alcohol-based sanitizers vs handwashing resulted in lower hand eczema severity index scores (n=108).16
Propensity for ICD is a limiting factor in hand hygiene adherence.17 In a double-blind randomized trial (N=54), scheduled use of an oil-containing lotion was shown to increase compliance with hand hygiene protocols in health care workers by preventing cracks, scaling, and pain.18 Using sanitizers containing humectants (eg, aloe vera gel) or moisturizers with petrolatum, liquid paraffin, glycerin, or mineral oil have all been shown to decrease the incidence of ICD in frequent handwashers.19,20 Thorough hand drying also is important in preventing dermatitis. Drying with disposable paper towels is preferred over automated air dryers to prevent aerosolization of microbes.21 Because latex has been implicated in development of ICD, use of latex-free gloves is recommended.22
Alcohol-based sanitizer is not only an effective virucidal agent but also is less likely to cause ICD, therefore promoting hand hygiene adherence. Handwashing with soap still is necessary when hands are visibly dirty but should be performed less frequently if feasible. Hand hygiene and emollient usage education is important for physicians and patients alike, particularly during the COVID-19 crisis.
Handwashing with antimicrobial soaps or alcohol-based sanitizers is an effective measure in preventing microbial disease transmission. In the context of coronavirus disease 2019 (COVID-19) prevention, the World Health Organization and Centers for Disease Control and Prevention have recommended handwashing with soap and water after coughing/sneezing, visiting a public place, touching surfaces outside the home, and taking care of a sick person(s), as well as before and after eating. When soap and water are not available, alcohol-based sanitizers may be used.1,2
Irritant contact dermatitis (ICD) is most commonly associated with wet work and is frequently seen in health care workers in relation to hand hygiene, with survey-based studies reporting 25% to 55% of nurses affected.3-5 In a prospective study (N=102), health care workers who washed their hands more than 10 times per day were55% more likely to develop hand dermatitis.6 Frequent ICD of the hands has been reported in Chinese health care workers in association with COVID-19.7 Handwashing and/or glove wearing may be newly prioritized by workers who handle frequently touched goods and surfaces, such as flight attendants (Figure). Patients with obsessive-compulsive disorder may be another vulnerable population.8

Alcohol-based sanitizers and detergents or antimicrobials in soaps may cause ICD of the hands by denaturation of stratum corneum proteins, depletion of intercellular lipids, and decreased corneocyte cohesion. These agents alter the skin flora, with increased colonization by staphylococci and gram-negative bacilli.9 Clinical findings include xerosis, scaling, fissuring, and bleeding. Physicians may evaluate severity of ICD of the hands using the
Cleansing the hands with alcohol-based sanitizers has consistently shown equivalent or greater efficacy than antimicrobial soaps for eradication of most microbes, with exception of bacterial spores and protozoan oocysts.11 In an in vivo experiment, 70% ethanol solution was more effective in eradicating rotavirus from the fingerpads of adults than 10% povidone-iodine solution, nonmedicated soaps, and soaps containing chloroxylenol 4.8% or chlorhexidine gluconate 4%.12 Coronavirus disease 2019 is a lipophilic enveloped virus. The lipid-dissolving effects of alcohol-based sanitizers is especially effective against these kinds of viruses. An in vitro experiment showed that alcohol solutions are effective against enveloped viruses including severe acute respiratory syndrome coronavirus, Ebola virus, and Zika virus.13 There are limited data for the virucidal efficacy of non–alcohol-based sanitizers containing quaternary ammonium compounds (most commonly benzalkonium chloride) and therefore they are not recommended for protection against COVID-19. Handwashing is preferred over alcohol-based solutions when hands are visibly dirty.
Alcohol-based sanitizers typically are less likely to cause ICD than handwashing with detergent-based or antimicrobial soaps. Antimicrobial ingredients in soaps such as chlorhexidine, chloroxylenol, and triclosan are frequent culprits.11 Detergents in soap such as sodium laureth sulfate cause more skin irritation and transepidermal water loss than alcohol14; however, among health care workers, alcohol-based sanitizers often are perceived as more damaging to the skin.15 During the 2014 Ebola outbreak, use of alcohol-based sanitizers vs handwashing resulted in lower hand eczema severity index scores (n=108).16
Propensity for ICD is a limiting factor in hand hygiene adherence.17 In a double-blind randomized trial (N=54), scheduled use of an oil-containing lotion was shown to increase compliance with hand hygiene protocols in health care workers by preventing cracks, scaling, and pain.18 Using sanitizers containing humectants (eg, aloe vera gel) or moisturizers with petrolatum, liquid paraffin, glycerin, or mineral oil have all been shown to decrease the incidence of ICD in frequent handwashers.19,20 Thorough hand drying also is important in preventing dermatitis. Drying with disposable paper towels is preferred over automated air dryers to prevent aerosolization of microbes.21 Because latex has been implicated in development of ICD, use of latex-free gloves is recommended.22
Alcohol-based sanitizer is not only an effective virucidal agent but also is less likely to cause ICD, therefore promoting hand hygiene adherence. Handwashing with soap still is necessary when hands are visibly dirty but should be performed less frequently if feasible. Hand hygiene and emollient usage education is important for physicians and patients alike, particularly during the COVID-19 crisis.
- Centers for Disease Control and Prevention. Coronavirus disease 2019. how to protect yourself & others. https://www.cdc.gov/coronavirus/2019-ncov/prepare/prevention.html. Updated April 13, 2020. Accessed April 21, 2020.
- World Health Organization. Coronavirus disease (COVID-19) advice for the public. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public. Updated March 31, 2020. Accessed April 21, 2020.
- Carøe TK, Ebbehøj NE, Bonde JPE, et al. Hand eczema and wet work: dose-response relationship and effect of leaving the profession. Contact Dermatitis. 2018;78:341-347.
- Larson E, Friedman C, Cohran J, et al. Prevalence and correlates of skin damage on the hands of nurses. Heart Lung. 1997;26:404-412.
- Lampel HP, Patel N, Boyse K, et al. Prevalence of hand dermatitis in inpatient nurses at a United States hospital. Dermatitis. 2007;18:140-142.
- Callahan A, Baron E, Fekedulegn D, et al. Winter season, frequent hand washing, and irritant patch test reactions to detergents are associated with hand dermatitis in health care workers. Dermatitis. 2013;24:170-175.
- Lan J, Song Z, Miao X, et al. Skin damage among healthcare workers managing coronavirus disease-2019 [published online March 18, 2020]. J Am Acad Dermatol. 2020;82:1215-1216.
- Katz RJ, Landau P, DeVeaugh-Geiss J, et al. Pharmacological responsiveness of dermatitis secondary to compulsive washing. Psychiatry Res. 1990;34:223-226.
- Larson EL, Hughes CA, Pyrek JD, et al. Changes in bacterial flora associated with skin damage on hands of health care personnel. Am J Infect Control. 1998;26:513-521.
- Held E, Skoet R, Johansen JD, et al. The hand eczema severity index (HECSI): a scoring system for clinical assessment of hand eczema. a study of inter- and intraobserver reliability. Br J Dermatol. 2005;152:302-307.
- Boyce JM, Pittet D, Healthcare Infection Control Practices Advisory Committee, et al. Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HIPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Am J Infect Control. 2002;30:S1-S46.
- Ansari SA, Sattar SA, Springthorpe VS, et al. Invivo protocol for testing efficacy of hand-washing agents against viruses and bacteria—experiments with rotavirus and Escherichi coli. Appl Environ Microbiol. 1989;55:3113-3118.
- Siddharta A, Pfaender S, Vielle NJ, et al. virucidal activity of world health organization-recommended formulations against enveloped viruses, including Zika, Ebola, and emerging coronaviruses. J Infect Dis. 2017;215:902-906.
- Pedersen LK, Held E, Johansen JD, et al. Less skin irritation from alcohol-based disinfectant than from detergent used for hand disinfection. Br J Dermatol. 2005;153:1142-1146.
- Stutz N, Becker D, Jappe U, et al. Nurses’ perceptions of the benefits and adverse effects of hand disinfection: alcohol-based hand rubs vs. hygienic handwashing: a multicentre questionnaire study with additional patch testing by the German Contact Dermatitis Research Group. Br J Dermatol. 2009;160:565-572.
- Wolfe MK, Wells E, Mitro B, et al. Seeking clearer recommendations for hand hygiene in communities facing Ebola: a randomized trial investigating the impact of six handwashing methods on skin irritation and dermatitis. PLoS One. 2016;11:e0167378.
- Pittet D, Allegranzi B, Storr J. The WHO Clean Care is Safer Care programme: field-testing to enhance sustainability and spread of hand hygiene improvements. J Infect Public Health. 2008;1:4-10.
- McCormick RD, Buchman TL, Maki DG. Double-blind, randomized trial of scheduled use of a novel barrier cream and an oil-containing lotion for protecting the hands of health care workers. Am J Infect Control. 2000;28:302-310.
- Berndt U, Wigger-Alberti W, Gabard B, et al. Efficacy of a barrier cream and its vehicle as protective measures against occupational irritant contact dermatitis. Contact Dermatitis. 2000;42:77-80.
- Kampf G, Ennen J. Regular use of a hand cream can attenuate skin dryness and roughness caused by frequent hand washing. BMC Dermatol. 2006;6:1.
- Gammon J, Hunt J. The neglected element of hand hygiene - significance of hand drying, efficiency of different methods, and clinical implication: a review. J Infect Prev. 2019;20:66-74.
- Elston DM. Letter from the editor: occupational skin disease among healthcare workers during the coronavirus (COVID-19) epidemic [published online March 18, 2020]. J Am Acad Dermatol. 2020;82:1085-1086.
- Centers for Disease Control and Prevention. Coronavirus disease 2019. how to protect yourself & others. https://www.cdc.gov/coronavirus/2019-ncov/prepare/prevention.html. Updated April 13, 2020. Accessed April 21, 2020.
- World Health Organization. Coronavirus disease (COVID-19) advice for the public. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public. Updated March 31, 2020. Accessed April 21, 2020.
- Carøe TK, Ebbehøj NE, Bonde JPE, et al. Hand eczema and wet work: dose-response relationship and effect of leaving the profession. Contact Dermatitis. 2018;78:341-347.
- Larson E, Friedman C, Cohran J, et al. Prevalence and correlates of skin damage on the hands of nurses. Heart Lung. 1997;26:404-412.
- Lampel HP, Patel N, Boyse K, et al. Prevalence of hand dermatitis in inpatient nurses at a United States hospital. Dermatitis. 2007;18:140-142.
- Callahan A, Baron E, Fekedulegn D, et al. Winter season, frequent hand washing, and irritant patch test reactions to detergents are associated with hand dermatitis in health care workers. Dermatitis. 2013;24:170-175.
- Lan J, Song Z, Miao X, et al. Skin damage among healthcare workers managing coronavirus disease-2019 [published online March 18, 2020]. J Am Acad Dermatol. 2020;82:1215-1216.
- Katz RJ, Landau P, DeVeaugh-Geiss J, et al. Pharmacological responsiveness of dermatitis secondary to compulsive washing. Psychiatry Res. 1990;34:223-226.
- Larson EL, Hughes CA, Pyrek JD, et al. Changes in bacterial flora associated with skin damage on hands of health care personnel. Am J Infect Control. 1998;26:513-521.
- Held E, Skoet R, Johansen JD, et al. The hand eczema severity index (HECSI): a scoring system for clinical assessment of hand eczema. a study of inter- and intraobserver reliability. Br J Dermatol. 2005;152:302-307.
- Boyce JM, Pittet D, Healthcare Infection Control Practices Advisory Committee, et al. Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HIPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Am J Infect Control. 2002;30:S1-S46.
- Ansari SA, Sattar SA, Springthorpe VS, et al. Invivo protocol for testing efficacy of hand-washing agents against viruses and bacteria—experiments with rotavirus and Escherichi coli. Appl Environ Microbiol. 1989;55:3113-3118.
- Siddharta A, Pfaender S, Vielle NJ, et al. virucidal activity of world health organization-recommended formulations against enveloped viruses, including Zika, Ebola, and emerging coronaviruses. J Infect Dis. 2017;215:902-906.
- Pedersen LK, Held E, Johansen JD, et al. Less skin irritation from alcohol-based disinfectant than from detergent used for hand disinfection. Br J Dermatol. 2005;153:1142-1146.
- Stutz N, Becker D, Jappe U, et al. Nurses’ perceptions of the benefits and adverse effects of hand disinfection: alcohol-based hand rubs vs. hygienic handwashing: a multicentre questionnaire study with additional patch testing by the German Contact Dermatitis Research Group. Br J Dermatol. 2009;160:565-572.
- Wolfe MK, Wells E, Mitro B, et al. Seeking clearer recommendations for hand hygiene in communities facing Ebola: a randomized trial investigating the impact of six handwashing methods on skin irritation and dermatitis. PLoS One. 2016;11:e0167378.
- Pittet D, Allegranzi B, Storr J. The WHO Clean Care is Safer Care programme: field-testing to enhance sustainability and spread of hand hygiene improvements. J Infect Public Health. 2008;1:4-10.
- McCormick RD, Buchman TL, Maki DG. Double-blind, randomized trial of scheduled use of a novel barrier cream and an oil-containing lotion for protecting the hands of health care workers. Am J Infect Control. 2000;28:302-310.
- Berndt U, Wigger-Alberti W, Gabard B, et al. Efficacy of a barrier cream and its vehicle as protective measures against occupational irritant contact dermatitis. Contact Dermatitis. 2000;42:77-80.
- Kampf G, Ennen J. Regular use of a hand cream can attenuate skin dryness and roughness caused by frequent hand washing. BMC Dermatol. 2006;6:1.
- Gammon J, Hunt J. The neglected element of hand hygiene - significance of hand drying, efficiency of different methods, and clinical implication: a review. J Infect Prev. 2019;20:66-74.
- Elston DM. Letter from the editor: occupational skin disease among healthcare workers during the coronavirus (COVID-19) epidemic [published online March 18, 2020]. J Am Acad Dermatol. 2020;82:1085-1086.
Practice Points
- Alcohol-based sanitizers are as or even more effective as handwashing with soap and water for preventing disease transmission of enveloped viruses such as severe acute respiratory syndrome coronavirus.
- Although perceived as more irritating, alcohol-based sanitizers are less likely to cause irritant contact dermatitis of the hands than handwashing with soap and water.
- Use of humectants, moisturizers, and/or emollients in combination with alcohol-based sanitizers allows for effective hand hygiene without irritating the skin.
Analysis of Education on Nail Conditions at the American Academy of Dermatology Annual Meetings
To the Editor:
The diagnosis and treatment of nail conditions are necessary competencies for board-certified dermatologists, but appropriate education often is lacking.1 The American Academy of Dermatology (AAD) annual meeting is one of the largest and most highly attended dermatology educational conferences worldwide. We sought to determine the number of hours dedicated to nail-related topics at the AAD annual meetings from 2013 to 2019.
We accessed programs from the AAD annual meetings archive online (https://www.aad.org/meetings/previous-meetings-archive), and we used hair and psoriasis content for comparison. Event titles and descriptions were searched for nail-related content (using search terms nail, onychia, and onycho), hair-related content (hair, alopecia, trichosis, hirsutism), and psoriasis content (psoriasis). Data acquired for each event included the date, hours, title, and event type (eg, forum, course, focus session, symposium, discussion group, workshop, plenary session).
The number of hours dedicated to nail education consistently lagged behind those related to hair and psoriasis content during the study period (Figure 1). According to the AAD, the conference runs Friday to Tuesday with higher attendance Friday to Sunday (Tim Moses, personal communication, July 9, 2019). Lectures during the weekend are likely to have a broader reach than lectures on Monday and Tuesday. The proportion of nail content during weekend prime time slots was similar to that of hair and psoriasis (Figure 2). Plenary sessions often are presented by renowned experts on hot topics in dermatology. Notably, hair (2014-2015) and psoriasis (2015-2017) content were represented in the plenary sessions during the study period, while nail content was not featured.


Our study shows that nail-related education was underrepresented at the AAD annual meetings from 2013 to 2019 compared to hair- and psoriasis-related content. Educational gaps in the diagnosis of fignail conditions previously have been delineated, and prioritization of instruction on nail disease pathology and diagnostic procedures has been recommended to improve patient care.1 The majority of nail unit melanomas are diagnosed at late stages, which has been attributed to deficiencies in clinical knowledge and failure to perform or inadequate biopsy techniques.2 Notably, a survey of third-year dermatology residents (N=240) assessing experience in procedural dermatology showed that 58% performed 10 or fewer nail procedures and 30% did not feel competent in performing nail surgery.3 Furthermore, a survey examining the management of longitudinal melanonychia among attending and resident dermatologists (N=402) found that 62% of residents and 28% of total respondents were not confident in managing melanonychia.4
A limitation of this study was the lack of online data available for AAD annual meetings before 2013, so we were unable to characterize any long-term trends. Furthermore, we were unable to assess the educational reach of these sessions, as data on attendance are lacking.
This study demonstrates a paucity of nail-related content at the AAD annual meetings. The introduction of the “Hands-on: Nail Surgery” in 2015 is an important step forward to diminish the knowledge gap in the diagnosis of various nail diseases and malignancies. We recommend increasing the number of hours and overall content of didactic nail sessions at the AAD annual meeting to further the knowledge and procedural skills of dermatologists in caring for patients with nail disorders.
- Hare AQ, R ich P. Clinical and educational gaps in diagnosis of nail disorders. Dermatol Clin. 2016;34:269-273.
- Tan KB, Moncrieff M, Thompson JF, et al. Subungual melanoma: a study of 124 cases highlighting features of early lesions, potential pitfalls in diagnosis, and guidelines for histologic reporting. Am J Surg Pathol. 2007;31:1902-1912.
- Lee EH, Nehal KS, Dusza SW, et al. Procedural dermatology training during dermatology residency: a survey of third-year dermatology residents. J Am Acad Dermatol. 2011;64:475-483.
- Halteh P, Scher R, Artis A, et al. A survey-based study of management of longitudinal melanonychia amongst attending and resident dermatologists. J Am Acad Dermatol. 2017;76:994-996.
To the Editor:
The diagnosis and treatment of nail conditions are necessary competencies for board-certified dermatologists, but appropriate education often is lacking.1 The American Academy of Dermatology (AAD) annual meeting is one of the largest and most highly attended dermatology educational conferences worldwide. We sought to determine the number of hours dedicated to nail-related topics at the AAD annual meetings from 2013 to 2019.
We accessed programs from the AAD annual meetings archive online (https://www.aad.org/meetings/previous-meetings-archive), and we used hair and psoriasis content for comparison. Event titles and descriptions were searched for nail-related content (using search terms nail, onychia, and onycho), hair-related content (hair, alopecia, trichosis, hirsutism), and psoriasis content (psoriasis). Data acquired for each event included the date, hours, title, and event type (eg, forum, course, focus session, symposium, discussion group, workshop, plenary session).
The number of hours dedicated to nail education consistently lagged behind those related to hair and psoriasis content during the study period (Figure 1). According to the AAD, the conference runs Friday to Tuesday with higher attendance Friday to Sunday (Tim Moses, personal communication, July 9, 2019). Lectures during the weekend are likely to have a broader reach than lectures on Monday and Tuesday. The proportion of nail content during weekend prime time slots was similar to that of hair and psoriasis (Figure 2). Plenary sessions often are presented by renowned experts on hot topics in dermatology. Notably, hair (2014-2015) and psoriasis (2015-2017) content were represented in the plenary sessions during the study period, while nail content was not featured.


Our study shows that nail-related education was underrepresented at the AAD annual meetings from 2013 to 2019 compared to hair- and psoriasis-related content. Educational gaps in the diagnosis of fignail conditions previously have been delineated, and prioritization of instruction on nail disease pathology and diagnostic procedures has been recommended to improve patient care.1 The majority of nail unit melanomas are diagnosed at late stages, which has been attributed to deficiencies in clinical knowledge and failure to perform or inadequate biopsy techniques.2 Notably, a survey of third-year dermatology residents (N=240) assessing experience in procedural dermatology showed that 58% performed 10 or fewer nail procedures and 30% did not feel competent in performing nail surgery.3 Furthermore, a survey examining the management of longitudinal melanonychia among attending and resident dermatologists (N=402) found that 62% of residents and 28% of total respondents were not confident in managing melanonychia.4
A limitation of this study was the lack of online data available for AAD annual meetings before 2013, so we were unable to characterize any long-term trends. Furthermore, we were unable to assess the educational reach of these sessions, as data on attendance are lacking.
This study demonstrates a paucity of nail-related content at the AAD annual meetings. The introduction of the “Hands-on: Nail Surgery” in 2015 is an important step forward to diminish the knowledge gap in the diagnosis of various nail diseases and malignancies. We recommend increasing the number of hours and overall content of didactic nail sessions at the AAD annual meeting to further the knowledge and procedural skills of dermatologists in caring for patients with nail disorders.
To the Editor:
The diagnosis and treatment of nail conditions are necessary competencies for board-certified dermatologists, but appropriate education often is lacking.1 The American Academy of Dermatology (AAD) annual meeting is one of the largest and most highly attended dermatology educational conferences worldwide. We sought to determine the number of hours dedicated to nail-related topics at the AAD annual meetings from 2013 to 2019.
We accessed programs from the AAD annual meetings archive online (https://www.aad.org/meetings/previous-meetings-archive), and we used hair and psoriasis content for comparison. Event titles and descriptions were searched for nail-related content (using search terms nail, onychia, and onycho), hair-related content (hair, alopecia, trichosis, hirsutism), and psoriasis content (psoriasis). Data acquired for each event included the date, hours, title, and event type (eg, forum, course, focus session, symposium, discussion group, workshop, plenary session).
The number of hours dedicated to nail education consistently lagged behind those related to hair and psoriasis content during the study period (Figure 1). According to the AAD, the conference runs Friday to Tuesday with higher attendance Friday to Sunday (Tim Moses, personal communication, July 9, 2019). Lectures during the weekend are likely to have a broader reach than lectures on Monday and Tuesday. The proportion of nail content during weekend prime time slots was similar to that of hair and psoriasis (Figure 2). Plenary sessions often are presented by renowned experts on hot topics in dermatology. Notably, hair (2014-2015) and psoriasis (2015-2017) content were represented in the plenary sessions during the study period, while nail content was not featured.


Our study shows that nail-related education was underrepresented at the AAD annual meetings from 2013 to 2019 compared to hair- and psoriasis-related content. Educational gaps in the diagnosis of fignail conditions previously have been delineated, and prioritization of instruction on nail disease pathology and diagnostic procedures has been recommended to improve patient care.1 The majority of nail unit melanomas are diagnosed at late stages, which has been attributed to deficiencies in clinical knowledge and failure to perform or inadequate biopsy techniques.2 Notably, a survey of third-year dermatology residents (N=240) assessing experience in procedural dermatology showed that 58% performed 10 or fewer nail procedures and 30% did not feel competent in performing nail surgery.3 Furthermore, a survey examining the management of longitudinal melanonychia among attending and resident dermatologists (N=402) found that 62% of residents and 28% of total respondents were not confident in managing melanonychia.4
A limitation of this study was the lack of online data available for AAD annual meetings before 2013, so we were unable to characterize any long-term trends. Furthermore, we were unable to assess the educational reach of these sessions, as data on attendance are lacking.
This study demonstrates a paucity of nail-related content at the AAD annual meetings. The introduction of the “Hands-on: Nail Surgery” in 2015 is an important step forward to diminish the knowledge gap in the diagnosis of various nail diseases and malignancies. We recommend increasing the number of hours and overall content of didactic nail sessions at the AAD annual meeting to further the knowledge and procedural skills of dermatologists in caring for patients with nail disorders.
- Hare AQ, R ich P. Clinical and educational gaps in diagnosis of nail disorders. Dermatol Clin. 2016;34:269-273.
- Tan KB, Moncrieff M, Thompson JF, et al. Subungual melanoma: a study of 124 cases highlighting features of early lesions, potential pitfalls in diagnosis, and guidelines for histologic reporting. Am J Surg Pathol. 2007;31:1902-1912.
- Lee EH, Nehal KS, Dusza SW, et al. Procedural dermatology training during dermatology residency: a survey of third-year dermatology residents. J Am Acad Dermatol. 2011;64:475-483.
- Halteh P, Scher R, Artis A, et al. A survey-based study of management of longitudinal melanonychia amongst attending and resident dermatologists. J Am Acad Dermatol. 2017;76:994-996.
- Hare AQ, R ich P. Clinical and educational gaps in diagnosis of nail disorders. Dermatol Clin. 2016;34:269-273.
- Tan KB, Moncrieff M, Thompson JF, et al. Subungual melanoma: a study of 124 cases highlighting features of early lesions, potential pitfalls in diagnosis, and guidelines for histologic reporting. Am J Surg Pathol. 2007;31:1902-1912.
- Lee EH, Nehal KS, Dusza SW, et al. Procedural dermatology training during dermatology residency: a survey of third-year dermatology residents. J Am Acad Dermatol. 2011;64:475-483.
- Halteh P, Scher R, Artis A, et al. A survey-based study of management of longitudinal melanonychia amongst attending and resident dermatologists. J Am Acad Dermatol. 2017;76:994-996.
Practice Points
- Diagnosis and treatment of nail conditions are necessary competencies for board-certified dermatologists, but appropriate education often is lacking.
- We recommend increasing the number of hours and overall content of didactic nail sessions at the American Academy of Dermatology annual meeting to further the knowledge and procedural skills of dermatologists caring for patients with nail disorders.
Evaluating the Impact and Educational Value of YouTube Videos on Nail Biopsy Procedures
To the Editor:
Nail biopsy is an important surgical procedure for diagnosis of nail pathology. YouTube has become a potential instrument for physicians and patients to learn about medical procedures.1,2 However, the sources, content, and quality of the information available have not been fully studied or characterized. Our objective was to analyze the efficiency of information and quality of YouTube videos on nail biopsies. We hypothesized that the quality of patient education and physician training videos would be unrepresentative on YouTube.
The term nail biopsy was searched on January 29, 2019, and filtered by relevance and rating using the default YouTube algorithm. Data were collected from the top 40 hits for the search term and filter coupling. All videos were viewed and sorted for nail biopsy procedures, and then those videos were categorized as being produced by a physician or other health care provider. The US medical board status of each physician videographer was determined using the American Board of Medical Specialties database.3 DISCERN criteria for assessing consumer health care information4 were used to interpret the videos by researchers (S.I. and S.R.L.) in this study.
From the queried search term collection, only 10 videos (1,023,423 combined views) were analyzed in this study (eTable). Although the other resulting videos were tagged as nail biopsy, they were excluded due to irrelevant content (eg, patient blogs, PowerPoints, nail avulsions). The mean age of the videos was 4 years (range, 4 days to 11 years), with a mean video length of 3.30 minutes (range, 49 seconds to 9.03 minutes). Four of 10 videos were performed for longitudinal melanonychia, and 5 of 10 videos were performed for melanonychia, clinically consistent with subungual hematoma. Dermatologists, plastic surgeons, and podiatrists produced the majority of the nail biopsy videos. The overall mean DISCERN rating was 1.60/5.00 (range, 1–3), meaning that the quality of content on nail biopsies was poor. This low DISCERN score signifies poor consumer health information. Video 2 (published in 2015) received a DISCERN score of 2 and received almost 1 million views, which is likely because the specific channel has a well-established subscriber pool (4.9 million subscribers). The highest DISCERN score of 3, demonstrating a tangential shave biopsy, was given to video 4 (published in 2010) and only received about 17,400 views (56 subscribers). Additionally, many videos lacked important information about the procedure. For instance, only 3 of 10 videos demonstrated the anesthetic technique and only 5 videos showed repair methods.
YouTube is an electronic learning source for general information; however, the content and quality of information on nail biopsy is not updated, reliable, or abundant. Patients undergoing nail biopsies are unlikely to find reliable and comprehensible information on YouTube; thus, there is a strong need for patient education in this area. In addition, physicians who did not learn to perform a nail biopsy during training are unlikely to learn this procedure from YouTube. Therefore, there is an unmet need for an outlet that will provide updated reliable content on nail biopsies geared toward both patients and physicians.
- Kwok TM, Singla AA, Phang K, et al. YouTube as a source of patient information for varicose vein treatment options. J Vasc Surg Venous Lymphat Disord. 2017;5:238-243.
- Ward B, Ward M, Nicheporuck A, et al. Assessment of YouTube as an informative resource on facial plastic surgery procedures. JAMA Facial Plastic Surgery. 2019;21:75-76.
- American Board of Medical Specialties. Certification Matters. https://www.certificationmatters.org. Accessed February 7, 2020.
- The DISCERN Instrument. DISCERN Online. http://www.discern.org.uk/discern_instrument.php. Published October 1999. Accessed February 7, 2020.
To the Editor:
Nail biopsy is an important surgical procedure for diagnosis of nail pathology. YouTube has become a potential instrument for physicians and patients to learn about medical procedures.1,2 However, the sources, content, and quality of the information available have not been fully studied or characterized. Our objective was to analyze the efficiency of information and quality of YouTube videos on nail biopsies. We hypothesized that the quality of patient education and physician training videos would be unrepresentative on YouTube.
The term nail biopsy was searched on January 29, 2019, and filtered by relevance and rating using the default YouTube algorithm. Data were collected from the top 40 hits for the search term and filter coupling. All videos were viewed and sorted for nail biopsy procedures, and then those videos were categorized as being produced by a physician or other health care provider. The US medical board status of each physician videographer was determined using the American Board of Medical Specialties database.3 DISCERN criteria for assessing consumer health care information4 were used to interpret the videos by researchers (S.I. and S.R.L.) in this study.
From the queried search term collection, only 10 videos (1,023,423 combined views) were analyzed in this study (eTable). Although the other resulting videos were tagged as nail biopsy, they were excluded due to irrelevant content (eg, patient blogs, PowerPoints, nail avulsions). The mean age of the videos was 4 years (range, 4 days to 11 years), with a mean video length of 3.30 minutes (range, 49 seconds to 9.03 minutes). Four of 10 videos were performed for longitudinal melanonychia, and 5 of 10 videos were performed for melanonychia, clinically consistent with subungual hematoma. Dermatologists, plastic surgeons, and podiatrists produced the majority of the nail biopsy videos. The overall mean DISCERN rating was 1.60/5.00 (range, 1–3), meaning that the quality of content on nail biopsies was poor. This low DISCERN score signifies poor consumer health information. Video 2 (published in 2015) received a DISCERN score of 2 and received almost 1 million views, which is likely because the specific channel has a well-established subscriber pool (4.9 million subscribers). The highest DISCERN score of 3, demonstrating a tangential shave biopsy, was given to video 4 (published in 2010) and only received about 17,400 views (56 subscribers). Additionally, many videos lacked important information about the procedure. For instance, only 3 of 10 videos demonstrated the anesthetic technique and only 5 videos showed repair methods.
YouTube is an electronic learning source for general information; however, the content and quality of information on nail biopsy is not updated, reliable, or abundant. Patients undergoing nail biopsies are unlikely to find reliable and comprehensible information on YouTube; thus, there is a strong need for patient education in this area. In addition, physicians who did not learn to perform a nail biopsy during training are unlikely to learn this procedure from YouTube. Therefore, there is an unmet need for an outlet that will provide updated reliable content on nail biopsies geared toward both patients and physicians.
To the Editor:
Nail biopsy is an important surgical procedure for diagnosis of nail pathology. YouTube has become a potential instrument for physicians and patients to learn about medical procedures.1,2 However, the sources, content, and quality of the information available have not been fully studied or characterized. Our objective was to analyze the efficiency of information and quality of YouTube videos on nail biopsies. We hypothesized that the quality of patient education and physician training videos would be unrepresentative on YouTube.
The term nail biopsy was searched on January 29, 2019, and filtered by relevance and rating using the default YouTube algorithm. Data were collected from the top 40 hits for the search term and filter coupling. All videos were viewed and sorted for nail biopsy procedures, and then those videos were categorized as being produced by a physician or other health care provider. The US medical board status of each physician videographer was determined using the American Board of Medical Specialties database.3 DISCERN criteria for assessing consumer health care information4 were used to interpret the videos by researchers (S.I. and S.R.L.) in this study.
From the queried search term collection, only 10 videos (1,023,423 combined views) were analyzed in this study (eTable). Although the other resulting videos were tagged as nail biopsy, they were excluded due to irrelevant content (eg, patient blogs, PowerPoints, nail avulsions). The mean age of the videos was 4 years (range, 4 days to 11 years), with a mean video length of 3.30 minutes (range, 49 seconds to 9.03 minutes). Four of 10 videos were performed for longitudinal melanonychia, and 5 of 10 videos were performed for melanonychia, clinically consistent with subungual hematoma. Dermatologists, plastic surgeons, and podiatrists produced the majority of the nail biopsy videos. The overall mean DISCERN rating was 1.60/5.00 (range, 1–3), meaning that the quality of content on nail biopsies was poor. This low DISCERN score signifies poor consumer health information. Video 2 (published in 2015) received a DISCERN score of 2 and received almost 1 million views, which is likely because the specific channel has a well-established subscriber pool (4.9 million subscribers). The highest DISCERN score of 3, demonstrating a tangential shave biopsy, was given to video 4 (published in 2010) and only received about 17,400 views (56 subscribers). Additionally, many videos lacked important information about the procedure. For instance, only 3 of 10 videos demonstrated the anesthetic technique and only 5 videos showed repair methods.
YouTube is an electronic learning source for general information; however, the content and quality of information on nail biopsy is not updated, reliable, or abundant. Patients undergoing nail biopsies are unlikely to find reliable and comprehensible information on YouTube; thus, there is a strong need for patient education in this area. In addition, physicians who did not learn to perform a nail biopsy during training are unlikely to learn this procedure from YouTube. Therefore, there is an unmet need for an outlet that will provide updated reliable content on nail biopsies geared toward both patients and physicians.
- Kwok TM, Singla AA, Phang K, et al. YouTube as a source of patient information for varicose vein treatment options. J Vasc Surg Venous Lymphat Disord. 2017;5:238-243.
- Ward B, Ward M, Nicheporuck A, et al. Assessment of YouTube as an informative resource on facial plastic surgery procedures. JAMA Facial Plastic Surgery. 2019;21:75-76.
- American Board of Medical Specialties. Certification Matters. https://www.certificationmatters.org. Accessed February 7, 2020.
- The DISCERN Instrument. DISCERN Online. http://www.discern.org.uk/discern_instrument.php. Published October 1999. Accessed February 7, 2020.
- Kwok TM, Singla AA, Phang K, et al. YouTube as a source of patient information for varicose vein treatment options. J Vasc Surg Venous Lymphat Disord. 2017;5:238-243.
- Ward B, Ward M, Nicheporuck A, et al. Assessment of YouTube as an informative resource on facial plastic surgery procedures. JAMA Facial Plastic Surgery. 2019;21:75-76.
- American Board of Medical Specialties. Certification Matters. https://www.certificationmatters.org. Accessed February 7, 2020.
- The DISCERN Instrument. DISCERN Online. http://www.discern.org.uk/discern_instrument.php. Published October 1999. Accessed February 7, 2020.
Practice Points
- A nail biopsy is sometimes necessary for histopathologic confirmation of a clinical diagnosis.
- YouTube has become a potential educational platform for physicians and patients to learn about nail biopsy procedures.
- Physicians and patients interested in learning more about nail biopsies are unlikely to find reliable and comprehensible information on YouTube; therefore, there is a need for updated reliable video content on nail biopsies geared toward both physicians and patients.